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Opposing function of mitochondrial prohibitin in aging

AutorArtal-Sanz, Marta ; Tavernarakis, Nektarios
Fecha de publicación2010
EditorImpact Journals
CitaciónAging 2(12): 1004-1011 (2010)
ResumenWhile specific signalling cascades involved in aging, such as the insulin/IGF‐1 pathway, are well‐described, the actual metabolic changes they elicit to prolong lifespan remain obscure. Nevertheless, the tuning of cellular metabolism towards maximal survival is the molecular basis of longevity. The eukaryotic mitochondrial prohibitin complex is a macromolecular structure at the inner mitochondrial membrane, implicated in several important cellular processes such as mitochondrial biogenesis and function, molecular signalling, replicative senescence, and cell death. Recent studies in C. elegans have revealed that prohibitin differentially influences aging by moderating fat metabolism and energy production, in response to both intrinsic signalling events and extrinsic cues. These findings indicate that prohibitin is a context‐dependent modulator of longevity. The tight evolutionary conservation and ubiquitous expression of prohibitin proteins suggest a similar role for the mitochondrial prohibitin complex during aging in other organisms.
DescripciónThis is an open‐access article distributed under the terms of the Creative Commons Attribution License.
Versión del editorhttp://www.impactaging.com/papers/v2/n12/full/100246.html
Identificadorese-issn: 1945-4589
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