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dc.contributor.authorDalmases, Mireiaes_ES
dc.contributor.authorPlanas, Anna M.es_ES
dc.contributor.authorTorres, Martaes_ES
dc.contributor.authorMárquez-Kisinousky, Leonardoes_ES
dc.contributor.authorAlmendros, Isaaces_ES
dc.contributor.authorEmbid, Cristinaes_ES
dc.contributor.authorMartínez, Miguel Ángeles_ES
dc.contributor.authorFarré, Ramones_ES
dc.contributor.authorMontserrat, Josep M.es_ES
dc.identifier.citation23rd Annual Congress European Respiratory Society (2013)es_ES
dc.descriptionPóster presentado en el 23rd Annual Congress European Respiratory Society (ERS) celebrado del 7 al 11 de septiembre de 2013 en Barcelona (España)es_ES
dc.descriptionAbstract publicado en "European Respiratory Journal" 42 (Suppl 57): 39s (2013)-
dc.description.abstractBackground:Obstructive sleep apnea (OSA) is over 50% in elderly population and cognitive impairment is a well-known consequence. It has been reported that both oxygen partial pressure (PtO2) and oxidative stress increase during recurrent apneas in brain tissue of young rats(Almendros et al. Sleep, 2011;34:1127–1133). It has also been recently demonstrated a lower mean increase and a decrease in PtO2 swings amplitude during apneas in older rats (ATS,2013), but it is not known whether this pattern translates into brain oxidative stress. Aim: To measure the brain oxidative stress in response to obstructive apneas in young and old rats. Methods: This study was carried out on 40 male Wistar rats: 20 young (12-weeks old) and 20 old (18-months old). The rats were non-invasively subjected to recurrent obstructive apneas (50 apneas/h, 15 s each) over 4 hours. Brain tissue samples were excised for measurement of the content of lipid peroxidation (LPO), using an Assay Kit, and antioxidant enzyme levels were determined by Western Blot. Results: LPO signifi cantly increased after apneas in young (p<0.01) but not in old rats. Superoxide dismutase, glutathione peroxidise-1, and gluthatione reductase increased after apneas, especially in the old rats (p<0.05)es_ES
dc.titleBrain oxidative stress induced by recurrent obstructive apneas: Old versus young ratses_ES
dc.typepóster de congresoes_ES
dc.description.peerreviewedPeer reviewedes_ES
Appears in Collections:(IIBB) Comunicaciones congresos
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