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Brain oxidative stress induced by recurrent obstructive apneas: Old versus young rats

AuthorsDalmases, Mireia; Planas, Anna M. ; Torres, Marta; Márquez-Kisinousky, Leonardo ; Almendros, Isaac; Embid, Cristina; Martínez, Miguel Ángel; Farré, Ramon; Montserrat, Josep M.
Issue Date8-Sep-2013
Citation23rd Annual Congress European Respiratory Society (2013)
AbstractBackground:Obstructive sleep apnea (OSA) is over 50% in elderly population and cognitive impairment is a well-known consequence. It has been reported that both oxygen partial pressure (PtO2) and oxidative stress increase during recurrent apneas in brain tissue of young rats(Almendros et al. Sleep, 2011;34:1127–1133). It has also been recently demonstrated a lower mean increase and a decrease in PtO2 swings amplitude during apneas in older rats (ATS,2013), but it is not known whether this pattern translates into brain oxidative stress. Aim: To measure the brain oxidative stress in response to obstructive apneas in young and old rats. Methods: This study was carried out on 40 male Wistar rats: 20 young (12-weeks old) and 20 old (18-months old). The rats were non-invasively subjected to recurrent obstructive apneas (50 apneas/h, 15 s each) over 4 hours. Brain tissue samples were excised for measurement of the content of lipid peroxidation (LPO), using an Assay Kit, and antioxidant enzyme levels were determined by Western Blot. Results: LPO signifi cantly increased after apneas in young (p<0.01) but not in old rats. Superoxide dismutase, glutathione peroxidise-1, and gluthatione reductase increased after apneas, especially in the old rats (p<0.05)
DescriptionPóster presentado en el 23rd Annual Congress European Respiratory Society (ERS) celebrado del 7 al 11 de septiembre de 2013 en Barcelona (España)
Abstract publicado en "European Respiratory Journal" 42 (Suppl 57): 39s (2013)
Appears in Collections:(IIBB) Comunicaciones congresos
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