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http://hdl.handle.net/10261/128767
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Campo DC | Valor | Lengua/Idioma |
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dc.contributor.author | Belik, Daria | es_ES |
dc.contributor.author | Tsang, Hilda | es_ES |
dc.contributor.author | Wharton, John | es_ES |
dc.contributor.author | Howard, Luke | es_ES |
dc.contributor.author | Bernabéu, Carmelo | es_ES |
dc.contributor.author | Wojciak-Stothard, Beata | es_ES |
dc.date.issued | 2016-01-19 | - |
dc.identifier.citation | Journal of Biomedical Science 23:4 (2016) | es_ES |
dc.identifier.issn | 1021-7770 | - |
dc.identifier.uri | http://hdl.handle.net/10261/128767 | - |
dc.description | 11 p.-4 fig.-1 tab. | es_ES |
dc.description.abstract | Background: Increased circulating levels of endoglin+ endothelial microparticles (EMPs) have been identified in several cardiovascular disorders, related to severity. Endoglin is an auxilary receptor for transforming growth factor β (TGF-β) important in the regulation of vascular structure. | es_ES |
dc.description.abstract | Results: We quantified the number of microparticles in plasma of six patients with chronic thromboembolic pulmonary hypertension (CTEPH) and age- and sex-matched pulmonary embolic (PE) and healthy controls and investigated the role of microparticle endoglin in the regulation of pulmonary endothelial function in vitro. Results show significantly increased levels of endoglin+ EMPs in CTEPH plasma, compared to healthy and disease controls. Co-culture of human pulmonary endothelial cells with CTEPH microparticles increased intracellular levels of endoglin and enhanced TGF-β-induced angiogenesis and Smad1,5,8 phosphorylation in cells, without affecting BMPRII expression. In an in vitro model, we generated endothelium-derived MPs with enforced membrane localization of endoglin. Co-culture of these MPs with endothelial cells increased cellular endoglin content, improved cell survival and stimulated angiogenesis in a manner similar to the effects induced by overexpressed protein. | es_ES |
dc.description.abstract | Conclusions: Increased generation of endoglin+ EMPs in CTEPH is likely to represent a protective mechanism supporting endothelial cell survival and angiogenesis, set to counteract the effects of vascular occlusion and endothelial damage. | es_ES |
dc.description.sponsorship | This research was supported by a project grant (PG 11/13/28765) from the British Heart Foundation and by grants from Ministerio de Economia y Competitividad of Spain (SAF2013-43421-R to CB) | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | BioMed Central | es_ES |
dc.relation | info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/SAF2013-43421-R | - |
dc.relation.isversionof | Publisher's version | es_ES |
dc.rights | openAccess | es_ES |
dc.subject | Endoglin | es_ES |
dc.subject | Angiogenesis | es_ES |
dc.subject | Pulmonary hypertension | es_ES |
dc.subject | Microparticles | es_ES |
dc.title | Endothelium-derived microparticles from chronically thromboembolic pulmonary hypertensive patients facilitate endothelial angiogenesis | es_ES |
dc.type | artículo | es_ES |
dc.identifier.doi | 10.1186/s12929-016-0224-9 | - |
dc.description.peerreviewed | Peer reviewed | es_ES |
dc.relation.publisherversion | http://dx.doi.org/ 10.1186/s12929-016-0224-9 | es_ES |
dc.identifier.e-issn | 1423-0127 | - |
dc.rights.license | https://creativecommons.org/publicdomain/zero/1.0/ | es_ES |
dc.contributor.funder | Ministerio de Economía y Competitividad (España) | es_ES |
dc.relation.csic | Sí | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100003329 | es_ES |
dc.identifier.pmid | 26786759 | - |
dc.type.coar | http://purl.org/coar/resource_type/c_6501 | es_ES |
item.openairetype | artículo | - |
item.grantfulltext | open | - |
item.cerifentitytype | Publications | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.fulltext | With Fulltext | - |
item.languageiso639-1 | en | - |
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JBS_Bernabéu_2016.pdf | Artículo principal | 1,93 MB | Adobe PDF | Visualizar/Abrir |
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