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CD200-CD200R1 system in neurological diseases: multiple sclerosis

AutorValente, Tony; Serratosa, Joan ; Perpiñá, Unai ; Saura, Josep ; Solà, Carme
Fecha de publicación22-oct-2014
CitaciónIX Simposi de Neurobiologia Experimental (2014)
ResumenMultiple sclerosis (MS) is a complex neurological disease. Although the etiology of MS is unknown, it is widely accepted that it is an inflammatory demyelinating disease of the central nervous system. Microglia play an important role in neurological diseases as executer of innate immunity to restore tissue homeostasis and minimize neuronal damage. However, the exacerbation of microglial activation seems to play a negative role in disease progression, since pro-inflammatory factors overproduction can contribute to neuronal death. Neurons have developed several inhibitory mechanisms to control microglia activation, such as CD200 (mainly neuronal) -CD200R1 (mainly microglial) interaction. Although the neuron-microglia interaction could be a therapeutic target to control glial activation/neuroinflammation, little is known about the mechanisms that regulate this interaction and very few studies are performed in human. In the present work, we studied the expression of CD200-CD200R1 system in an animal experimental model of MS (EAE, experimental autoimmune encephalomyelitis) and in human brain postmortem samples from MS patients. In the EAE model, CD200R1 expression in several spinal cord regions is increased at symptomatic disease phase, while CD200 expression is decreased at both pre-symptomatic and symptomatic phases. In the brain, CD200R1 and CD200 expression are also altered. In MS human samples no significant alterations were observed in mRNA expression for both CD200R1 and CD200. However, CD200R1 protein was increased and CD200 protein was decreased. Therefore, CD200-CD200R1 system may be differentially expressed during development and progression of multiple sclerosis, which suggests that a modulation of CD200-CD200R1 could be a good tool to control microglial activation in this neurological disease
DescripciónPóster presentado en el IX Simposi de Neurobiologia Experimental, celebrado los días 22 y 23 de octubre de 2014 en Barcelona y organizado por la Societat Catalana de Biologia del Institut d'Estudis Catalans
URIhttp://hdl.handle.net/10261/128403
Aparece en las colecciones: (IIBB) Comunicaciones congresos
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