English   español  
Por favor, use este identificador para citar o enlazar a este item: http://hdl.handle.net/10261/128146
COMPARTIR / IMPACTO:
Estadísticas
logo share SHARE   Add this article to your Mendeley library MendeleyBASE
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:
Título

Secreted frizzled-related proteins are required for Wnt/beta-catenin signalling activation in the vertebrate optic cup.

AutorEsteve, Pilar ; Sandonis Consuegra, África ; Ibáñez Pérez, Carmen ; Shimono, Akihiko; Guerrero Vega, Isabel ; Bovolenta, Paola
Palabras claveMouse
Drosophila
Patterning
Ciliary margin
Wnt diffusion
Fecha de publicación2011
EditorPalgrave Macmillan
CitaciónDevelopment 138: 4179 (2011)
ResumenSecreted frizzled-related proteins (Sfrps) are considered Wnt signalling antagonists but recent studies have shown that specific family members enhance Wnt diffusion and thus positively modulate Wnt signalling. Whether this is a general and physiological property of all Sfrps remains unexplored. It is equally unclear whether disruption of Sfrp expression interferes with developmental events mediated by Wnt signalling activation. Here, we have addressed these questions by investigating the functional consequences of Sfrp disruption in the canonical Wnt signalling-dependent specification of the mouse optic cup periphery. We show that compound genetic inactivation of Sfrp1 and Sfrp2 prevents Wnt/-catenin signalling activation in this structure, which fails to be specified and acquires neural retina characteristics. Consistent with a positive role of Sfrps in signalling activation, Wnt spreading is impaired in the retina of Sfrp1–/–;Sfrp2–/– mice. Conversely, forced expression of Sfrp1 in the wing imaginal disc of Drosophila, the only species in which the endogenous Wnt distribution can be detected, flattens the Wg gradient, suppresses the expression of high-Wg target genes but expands those typically activated by low Wg concentrations. Collectively, these data demonstrate that, in vivo, the levels of Wnt signalling activation strongly depend on the tissue distribution of Sfrps, which should be viewed as multifunctional regulators of Wnt signalling.
URIhttp://hdl.handle.net/10261/128146
Identificadoresissn: 1011-6370
Aparece en las colecciones: (CBM) Artículos
Ficheros en este ítem:
Fichero Descripción Tamaño Formato  
Bovolenta_p-SecretedFrizzled-RelatedProteins.pdf2,91 MBAdobe PDFVista previa
Visualizar/Abrir
Mostrar el registro completo
 


NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.