English   español  
Por favor, use este identificador para citar o enlazar a este item: http://hdl.handle.net/10261/127918
COMPARTIR / IMPACTO:
Estadísticas
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:
Título

Members of the TEAD family of transcription factors regulate the expression of Myf5 in ventral somitic compartments

AutorRibas, Ricardo; Moncaut, Natalia; Siligan, Christine; Taylor, Kevin; Cross, Joe W.; Rigby, Peter W. J.; Carvajal, Jaime J.
Palabras claveMyogenic regulatory factor
Myogenesis
Somite
Dermomyotome
Transcription regulation
TEAD
Myf5
Mrf4
Fecha de publicación15-jul-2011
EditorElsevier
CitaciónDevelopmental Biology 355(2): 372-380 (2011)
ResumenThe transcriptional regulation of the Mrf4/Myf5 locus depends on a multitude of enhancers that, in equilibria with transcription balancing sequences and the promoters, regulate the expression of the two genes throughout embryonic development and in the adult. Transcription in a particular set of muscle progenitors can be driven by the combined outputs of several enhancers that are not able to recapitulate the entire expression pattern in isolation, or by the action of a single enhancer the activity of which in isolation is equivalent to that within the context of the locus. We identified a new enhancer element of this second class, ECR111, which is highly conserved in all vertebrate species and is necessary and sufficient to drive Myf5 expression in ventro-caudal and ventro-rostral somitic compartments in the mouse embryo. EMSA analyses and data obtained from binding-site mutations in transgenic embryos show that a binding site for a TEA Domain (TEAD) transcription factor is essential for the function of this new enhancer, while ChIP assays show that at least two members of the family of transcription factors bind to it in vivo.
DescripciónUnder a Creative Commons license.
Versión del editorhttp://dx.doi.org/10.1016/j.ydbio.2011.04.005
URIhttp://hdl.handle.net/10261/127918
DOI10.1016/j.ydbio.2011.04.005
Identificadoresissn: 0012-1606
Aparece en las colecciones: (CABD) Artículos
Ficheros en este ítem:
Fichero Descripción Tamaño Formato  
TEAD_family_Ribas.pdf1,41 MBAdobe PDFVista previa
Visualizar/Abrir
Mostrar el registro completo
 

Artículos relacionados:


NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.