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Title

Genetic variation in the tau protein phosphatase-2A pathway is not associated with Alzheimer's disease risk

AuthorsVázquez-Higuera, José Luis; Valdivieso Amate, Fernando; Combarros, Onofre
Issue Date2011
PublisherBioMed Central
CitationBMC Research Notes 4 (2011)
AbstractBackground: Tau abnormal hyperphosphorylation and the formation of neurofibrillary tangles in AD brain is the result of upregulation of tau kinases and downregulation of tau phosphatases. Methods. In a group of 729 Spanish late-onset Alzheimer's disease (AD) patients and 670 healthy controls, we examined variations into a set of candidate genes (PPP2CA, PPP2R2A, ANP32A, LCMT1, PPME1 and PIN1) in the tau protein phosphatase-2A (PP2A) pathway, to address hypotheses of genetic variation that might influence AD risk. Results: There were no differences in the genotypic, allelic or haplotypic distributions between cases and controls in the overall analysis or after stratification by age, gender or APOE 4 allele. Conclusion: Our negative findings in the Spanish population argue against the hypothesis that genetic variation in the tau protein phosphatase-2A (PP2A) pathway is causally related to AD risk. © 2011 Combarros et al; licensee BioMed Central Ltd.
URIhttp://hdl.handle.net/10261/127725
DOI10.1186/1756-0500-4-327
Identifiersdoi: 10.1186/1756-0500-4-327
issn: 1756-0500
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