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Genome, transcriptome, and functional analyses of Penicillium expansum provide new insights into secondary metabolism and pathogenicity

AuthorsBallester Frutos, Ana Rosa ; Marcet-Houben, Marina; Levin, E.; Sela, N.; Selma Lázaro, Cristina ; Carmona, Lourdes ; Wisniewski, M.; Droby, S.; González-Candelas, Luis ; Gabaldón, Toni
KeywordsPathogenic fungi
Secondary metabolism
Penicillium expansum
Issue Date2015
PublisherAmerican Phytopathological Society
CitationMolecular Plant-Microbe Interactions 28: 232- 248 (2015)
AbstractThe relationship between secondary metabolism and infection in pathogenic fungi has remained largely elusive. The genus Penicillium comprises a group of plant pathogens with varying host specificities and with the ability to produce a wide array of secondary metabolites. The genomes of three Penicillium expansum strains, the main postharvest pathogen of pome fruit, and one Pencillium italicum strain, a postharvest pathogen of citrus fruit, were sequenced and compared with 24 other fungal species. A genomic analysis of gene clusters responsible for the production of secondary metabolites was performed. Putative virulence factors in P. expansum were identified by means of a transcriptomic analysis of apple fruits during the course of infection. Despite a major genome contraction, P. expansum is the Penicillium species with the largest potential for the production of secondary metabolites. Results using knockout mutants clearly demonstrated that neither patulin nor citrinin are required by P. expansum to successfully infect apples.
Identifiersdoi: 10.1094/MPMI-09-14-0261-FI
issn: 0894-0282
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