English   español  
Por favor, use este identificador para citar o enlazar a este item: http://hdl.handle.net/10261/127570
Título

2-Dimensional, pH-responsive oligoglycine-based nanocarriers

AutorGarriga, Rosa; Jurewicz, Izabela; Romero, Elena; Jarne, Carmen; Cebolla, Vicente L.; Dalton, Alan B.; Muñoz, Edgar
Palabras claveOligoglycine
Tectomers
Nanocarriers
pH-controlled release
Fluorescence
Fecha de publicación5-ene-2016
EditorAmerican Chemical Society
CitaciónACS Applied Materials and Interfaces
ResumenThe nanocarrier capabilities of atomically smooth 2-dimensional sheets of a biantennary oligoglycine peptide C8H16(-CH2-NH-Gly5)2 (also called tectomers) are demonstrated. We show that the pH-controlled, rapid and reversible assembly and disassembly of oligoglycine can be effectively used for controlled loading and release of the anticancer drug and fluorescent probe coralyne. The calculated partition coefficient in water is of the same order of magnitude or higher when compared to other nanocarriers such as liposomes and micelles, signifying the tectomer’s impressive loading capabilities. Moreover, the loading of guest molecules in tectomers facilitates the protection from rapid photochemically-induced degradation. Such efficient, pH-sensitive, stable and biocompatible nanocarriers are extremely attractive for biosensing, therapeutic and theranostic applications. Additionally, our results suggest that these planar self-assembled materials can also act as phase-transfer vehicles for hydrophobic cargoes further broadening their biomedical and technological applications.
Descripción"In Press"
Versión del editorhttp://dx.doi.org/10.1021/acsami.5b10077
URIhttp://hdl.handle.net/10261/127570
DOI10.1021/acsami.5b10077
ISSN1944-8244
E-ISSN1944-8252
Aparece en las colecciones: (ICB) Artículos
Ficheros en este ítem:
Fichero Descripción Tamaño Formato  
2-dimensional_Garriga.pdf2,79 MBAdobe PDFVista previa
Visualizar/Abrir
Mostrar el registro completo
 

Artículos relacionados:


NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.