English   español  
Por favor, use este identificador para citar o enlazar a este item: http://hdl.handle.net/10261/127422
COMPARTIR / IMPACTO:
Estadísticas
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:
Título

Snake Venomics and Antivenomics of Bothrops diporus, a Medically Important Pitviper in Northeastern Argentina

AutorGay, Carolina; Sanz, Libia ; Calvete, Juan J. ; Pla, Davinia
Palabras claveBothrops diporus venom
Venomics
Snake venom proteome
Antivenomics
Mass spectrometry
Fecha de publicación25-dic-2015
EditorMultidisciplinary Digital Publishing Institute
CitaciónToxins 8(1): E9. (2015)
ResumenSnake species within genus Bothrops are responsible for more than 80% of the snakebites occurring in South America. The species that cause most envenomings in Argentina, B. diporus, is widely distributed throughout the country, but principally found in the Northeast, the region with the highest rates of snakebites. The venom proteome of this medically relevant snake was unveiled using a venomic approach. It comprises toxins belonging to fourteen protein families, being dominated by PI- and PIII-SVMPs, PLA₂ molecules, BPP-like peptides, L-amino acid oxidase and serine proteinases. This toxin profile largely explains the characteristic pathophysiological effects of bothropic snakebites observed in patients envenomed by B. diporus. Antivenomic analysis of the SAB antivenom (Instituto Vital Brazil) against the venom of B. diporus showed that this pentabothropic antivenom efficiently recognized all the venom proteins and exhibited poor affinity towards the small peptide (BPPs and tripeptide inhibitors of PIII-SVMPs) components of the venom.
Descripción13 páginas, 3 figuras, 1 tabla adjunta como material suplementario
Versión del editorhttp://dx.doi.org/10.3390/toxins8010009
URIhttp://hdl.handle.net/10261/127422
DOI10.3390/toxins8010009
E-ISSN2072-6651
Aparece en las colecciones: (IBV) Artículos
Ficheros en este ítem:
Fichero Descripción Tamaño Formato  
Toxins-08-00009-supla mat.xlsxmaterial suplemetario56,6 kBMicrosoft Excel XMLVisualizar/Abrir
2015 Toxins 008-00009.pdfArtículo principal 1,88 MBAdobe PDFVista previa
Visualizar/Abrir
Mostrar el registro completo
 

Artículos relacionados:


NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.