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Título:	Hepatoprotective effect of CeO2 nanoparticles in rats treated with CCl4
Autor:	Oró, Denise; Casals, Eudald CSIC ORCID; Puntes, Víctor F. CSIC ORCID
Fecha de publicación:	2014
Editor:	European Association for the Study of the Liver
Citación:	49th Annual Meeting of the European Association for the Study of the Liver (2014)
Resumen:	[Background and Aims]: Deregulated inflammatory response plays a central role in the pathogenesis of cirrhosis. CeO2-nanoparticles (CeO2NPs) represent a novel agent to protect tissues from damage by their regenerative free radical scavenging properties. The study was aimed to analyze the bio-distribution of CeO2NPs and to assess the effects on hemodynamics and inflammation in CCl4-treated rats. [Methods]: First, we analyzed the organ distribution of nanoparticles in fibrotic rats using inductively coupled plasma mass spectrometry (ICP-MS) and magnetic resonance imaging (MRI). Next, CeO2NPs (0.1 mg/kg) or vehicle were administered intravenously twice/week for two weeks in CCl4-treated rats. Mean arterial pressure (MAP) and portal pressure (PP) were measured after 8 weeks of starting administration. Serum was used to measure standard hepatic and renal function tests. Liver tissue mRNA expression of proinflammatory genes was determined by RT-qPCR. [Results]: The highest concentration of CeO2NPs was found in the liver, followed by the spleen and kidney. Similar results were observed by MRI. A significant decrease in PP was observed in rats treated with CeO2NPs without any changes in MAP. CeO2NPs administration resulted in significantly lower serum levels of LDH and ALT. Treatment with CeO2NPs induced a marked reduction in the expression of pro-inflammatory cytokines (TNFa, IL1b) in the liver. [Conclusions]: CeO2NPs administration in fibrotic rats prevents the activation of liver damage markers and the expression of proinflammatory genes, thereby ameliorating portal hypertension. Since these compounds selectively target the liver, our results suggest that CeO2NPs may constitute a new therapeutic tool to arrest chronic inflammation in liver disease.
Descripción:	Resumen del póster presentado al International Liver Congress-49th Annual Meeting of the European Association for the Study of the Liver, celebrado del 9 al 13 de Abril de 2014 en London (UK).-- et al.
URI:	http://hdl.handle.net/10261/127156
Aparece en las colecciones:	(CIN2) Comunicaciones congresos