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dc.contributor.authorDonadel, Osvaldo J.en_US
dc.contributor.authorMartín, Tomásen_US
dc.contributor.authorMartín, Víctor S.en_US
dc.contributor.authorPadrón, José M.en_US
dc.date.accessioned2009-04-29T09:57:06Z-
dc.date.available2009-04-29T09:57:06Z-
dc.date.issued2007-01-01en_US
dc.identifier.citationBioorganic & Medicinal Chemistry Letters 17(1): 18-21 (2007)en_US
dc.identifier.issn0960-894X-
dc.identifier.urihttp://hdl.handle.net/10261/12693-
dc.description4 pages, 1 figure, 2 tables, 1 scheme.-- PMID: 17055722 [PubMed].-- Available online Oct 6, 2006.-
dc.description.abstractSamarium(II) iodide promotes the stereoselective synthesis of cis-β-alkoxy-γ-alkyl-γ-lactones under mild conditions starting from linear precursors. The in vitro antiproliferative activities were examined in the human solid tumor cell lines from diverse origin A2780, SW1573, and WiDr. From the growth inhibition data a structure–activity relationship was obtained. Overall the results point to the relevant role of cis-β-alkoxy-γ-alkyl-γ-lactones as novel scaffolds for the development of new anticancer drugs.-
dc.description.sponsorshipThis research was supported by the EU INTERREG IIIB-MAC initiative (05/MAC/2.5/C14 BIOPOLIS), the Ministerio de Educación y Ciencia of Spain, co-financed by the European Regional Development Fund (CTQ2005-09074-C02-01/BQU) and the Canary Islands Government. O.J.D. thanks the Canary Islands Government for a postdoctoral fellowship.-
dc.format.extent2373 bytes-
dc.format.extent160863 bytes-
dc.format.mimetypetext/plain-
dc.format.mimetypeapplication/pdf-
dc.language.isoengen_US
dc.publisherElsevier-
dc.rightsclosedAccessen_US
dc.subjectγ-Lactones-
dc.subjectSamarium(II) iodide-
dc.subjectAnticancer drugs-
dc.subjectSolid tumors-
dc.subjectStructure–activity relationship-
dc.titleSamarium(II) promoted stereoselective synthesis of antiproliferative cis-β-alkoxy-γ-alkyl-γ-lactonesen_US
dc.typeartículoen_US
dc.identifier.doi10.1016/j.bmcl.2006.10.005-
dc.relation.publisherversionhttp://dx.doi.org/10.1016/j.bmcl.2006.10.005-
dc.contributor.funderEuropean Commission-
dc.contributor.funderMinisterio de Educación y Ciencia (España)-
dc.contributor.funderGobierno de Canarias-
dc.identifier.funderhttp://dx.doi.org/10.13039/501100000780es_ES
dc.type.coarhttp://purl.org/coar/resource_type/c_6501es_ES
item.openairetypeartículo-
item.cerifentitytypePublications-
item.languageiso639-1en-
item.grantfulltextnone-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.fulltextNo Fulltext-
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