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http://hdl.handle.net/10261/12693
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Campo DC | Valor | Lengua/Idioma |
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dc.contributor.author | Donadel, Osvaldo J. | en_US |
dc.contributor.author | Martín, Tomás | en_US |
dc.contributor.author | Martín, Víctor S. | en_US |
dc.contributor.author | Padrón, José M. | en_US |
dc.date.accessioned | 2009-04-29T09:57:06Z | - |
dc.date.available | 2009-04-29T09:57:06Z | - |
dc.date.issued | 2007-01-01 | en_US |
dc.identifier.citation | Bioorganic & Medicinal Chemistry Letters 17(1): 18-21 (2007) | en_US |
dc.identifier.issn | 0960-894X | - |
dc.identifier.uri | http://hdl.handle.net/10261/12693 | - |
dc.description | 4 pages, 1 figure, 2 tables, 1 scheme.-- PMID: 17055722 [PubMed].-- Available online Oct 6, 2006. | - |
dc.description.abstract | Samarium(II) iodide promotes the stereoselective synthesis of cis-β-alkoxy-γ-alkyl-γ-lactones under mild conditions starting from linear precursors. The in vitro antiproliferative activities were examined in the human solid tumor cell lines from diverse origin A2780, SW1573, and WiDr. From the growth inhibition data a structure–activity relationship was obtained. Overall the results point to the relevant role of cis-β-alkoxy-γ-alkyl-γ-lactones as novel scaffolds for the development of new anticancer drugs. | - |
dc.description.sponsorship | This research was supported by the EU INTERREG IIIB-MAC initiative (05/MAC/2.5/C14 BIOPOLIS), the Ministerio de Educación y Ciencia of Spain, co-financed by the European Regional Development Fund (CTQ2005-09074-C02-01/BQU) and the Canary Islands Government. O.J.D. thanks the Canary Islands Government for a postdoctoral fellowship. | - |
dc.format.extent | 2373 bytes | - |
dc.format.extent | 160863 bytes | - |
dc.format.mimetype | text/plain | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | en_US |
dc.publisher | Elsevier | - |
dc.rights | closedAccess | en_US |
dc.subject | γ-Lactones | - |
dc.subject | Samarium(II) iodide | - |
dc.subject | Anticancer drugs | - |
dc.subject | Solid tumors | - |
dc.subject | Structure–activity relationship | - |
dc.title | Samarium(II) promoted stereoselective synthesis of antiproliferative cis-β-alkoxy-γ-alkyl-γ-lactones | en_US |
dc.type | artículo | en_US |
dc.identifier.doi | 10.1016/j.bmcl.2006.10.005 | - |
dc.relation.publisherversion | http://dx.doi.org/10.1016/j.bmcl.2006.10.005 | - |
dc.contributor.funder | European Commission | - |
dc.contributor.funder | Ministerio de Educación y Ciencia (España) | - |
dc.contributor.funder | Gobierno de Canarias | - |
dc.identifier.funder | http://dx.doi.org/10.13039/501100000780 | es_ES |
dc.type.coar | http://purl.org/coar/resource_type/c_6501 | es_ES |
item.openairetype | artículo | - |
item.cerifentitytype | Publications | - |
item.languageiso639-1 | en | - |
item.grantfulltext | none | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.fulltext | No Fulltext | - |
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