English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/12693
Share/Impact:
Statistics
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:

Title

Samarium(II) promoted stereoselective synthesis of antiproliferative cis-β-alkoxy-γ-alkyl-γ-lactones

AuthorsDonadel, Osvaldo J.; Martín, Tomás ; Martín, Víctor S.; Padrón, José M.
Keywordsγ-Lactones
Samarium(II) iodide
Anticancer drugs
Solid tumors
Structure–activity relationship
Issue Date1-Jan-2007
PublisherElsevier
CitationBioorganic & Medicinal Chemistry Letters 17(1): 18-21 (2007)
AbstractSamarium(II) iodide promotes the stereoselective synthesis of cis-β-alkoxy-γ-alkyl-γ-lactones under mild conditions starting from linear precursors. The in vitro antiproliferative activities were examined in the human solid tumor cell lines from diverse origin A2780, SW1573, and WiDr. From the growth inhibition data a structure–activity relationship was obtained. Overall the results point to the relevant role of cis-β-alkoxy-γ-alkyl-γ-lactones as novel scaffolds for the development of new anticancer drugs.
Description4 pages, 1 figure, 2 tables, 1 scheme.-- PMID: 17055722 [PubMed].-- Available online Oct 6, 2006.
Publisher version (URL)http://dx.doi.org/10.1016/j.bmcl.2006.10.005
URIhttp://hdl.handle.net/10261/12693
DOI10.1016/j.bmcl.2006.10.005
ISSN0960-894X
Appears in Collections:(IPNA) Artículos
Files in This Item:
There are no files associated with this item.
Show full item record
Review this work
 

Related articles:


WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.