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Title: | Synthesis and antiproliferative activity of (2R,3R)-disubstituted tetrahydropyrans. Part 2: Effect of side chain homologation |
Authors: | Carrillo Fumero, Romen CSIC ORCID ; León, Leticia G.; Martín, Tomás CSIC ORCID ; Martín, Víctor S.; Padrón, José M. | Keywords: | Marine products Anticancer drugs Cyclic ethers Solid tumors Structure-activity relationship |
Issue Date: | 1-Feb-2007 | Publisher: | Elsevier | Citation: | Bioorganic & Medicinal Chemistry Letters 17(3): 780-783 (2007) | Abstract: | In this study, we synthesized a series of enantiomerically pure (2R,3R)- and (2R,3S)-disubstituted tetrahydropyrans bearing a CH2O spacer group on the side chain at position 2 of the heterocyclic ring. The in vitro antiproliferative activities of the compounds were examined in the human solid tumor cell lines A2780 (ovarian cancer), SW1573 (non-small cell lung cancer), and WiDr (colon cancer). Overall, the results point out the relevance for antiproliferative activity of the distance between the heterocycle and the unsaturated group. | Description: | 4 pages, 2 figures, 1 table.-- PMID: 17110107 [PubMed].-- Available online Oct 27, 2006. | Publisher version (URL): | http://dx.doi.org/10.1016/j.bmcl.2006.10.066 | URI: | http://hdl.handle.net/10261/12692 | DOI: | 10.1016/j.bmcl.2006.10.066 | ISSN: | 0960-894X |
Appears in Collections: | (IPNA) Artículos |
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