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Method for obtaining useful information for the diagnosis of neuromuscular diseases

AuthorsEscudero, Luis M. ; Montero-Sánchez, Adoración; Paradas, Carmen; Rivas Infante, Eloy; Pascual Bravo, Alberto ; Sáez, Aurora; Serrano Gotarredona, Carmen; Acha Piñero, Begoña
Issue Date23-May-2013
CitationWO2013072543 A8
Abstract[EN] Method for obtaining useful information for the diagnosis of neuromuscular diseases. The invention describes a method for obtaining, on the basis of a patient biopsy, new parameters that allow objective diagnosis of different neuromuscular diseases and the degree to which these affect the patient, comprising: -staining the biopsy sample in order to highlight type-I muscle fibres, type-II muscle fibres and endomysium; - obtaining an image of the biopsy sample after staining; - dividing the image into segments to identify the outlines of the muscle fibres; - forming a network in which the muscle fibres constitute nodes and the contacts between muscle fibres constitute the connections between the nodes; - forming a vector characteristic of the biopsy sample, the elements of which are chosen from geometric parameters of the fibres and parameters of the network constructed; - and comparing control and affected biopsy samples by means of ACP using, in each case, the characteristic vector selected.
[ES] La invención describe un método para obtener, a partir de la biopsia de un paciente, nuevos parámetros que permiten diagnosticar de manera objetiva diferentes enfermedades neuromusculares y su grado de afectación al paciente, que comprende: -teñir la biopsia para resaltar fibras musculares tipo I, fibras musculares tipo II y endomisio; -obtener una imagen de la biopsia tras la tinción; -segmentar la imagen para identificar los contornos de las fibras musculares; -formar una red donde las fibras musculares constituyen nodos y los contactos entre fibras musculares constituyen las uniones entre los nodos; -formar un vector característico de la biopsia cuyos elementos se eligen entre parámetros geométricos de las fibras y parámetros de la red construida; y -comparar biopsias control y afectas por medio de ACP utilizando en cada caso el vector característico seleccionado.
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