English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/126712
logo share SHARE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:


Role of Src family kinases in prolactin signaling

AuthorsMartín-Pérez, Jorge ; García-Martínez, José Manuel ; Sánchez-Bailón, María Pilar; Mayoral-Varo, Víctor; Calcabrini, Annarica
Issue Date2015
CitationRewcent Advances in Prolactin Research (Cap.7): 163-188 (2015)
SeriesAdvances in Experimental Medicine and Biology
AbstractProlactin (PRL) is a polypeptide hormone/cytokine mainly synthesized by the lactotrophic cells of the adenohypophysis. In addition to the best-known role in mammary gland development and the functional differentiation of its epithelium, PRL is involved in regulation of multiple physiological processes in higher organisms contributing to their homeostasis. PRL has been also associated with pathology, including breast cancer. Therefore, it is relevant to determine the molecular mechanisms by which PRL controls cellular functions. Here, we analyze the role of Src family kinases (SFKs) in the intracellular signaling pathways controlled by PRL in several model systems. The data show that SFKs are essential components in transmitting signals upon PRL receptor stimulation, as they control activation of Jak2/Stat5 and other routes that regulate PRL cellular responses.
Identifiersdoi: 10.1007/978-3-319-12114-7_7
isbn: 978-3-319-12113-0
Appears in Collections:(IIBM) Libros y partes de libros
Files in This Item:
File Description SizeFormat 
accesoRestringido.pdf15,38 kBAdobe PDFThumbnail
Show full item record
Review this work

Related articles:

WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.