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| Título: | CholesteroNitrones for Stroke |
Autor: | Ayuso, M. I.; Chioua, Mourad CSIC ORCID ; Martínez-Alonso, E.; Soriano, Elena CSIC; Montaner, Joan CSIC ORCID; Masjuán, J.; Hadjipavlou-Litina, Dimitra; Marco-Contelles, José CSIC ORCID; Alcázar, Alberto | Fecha de publicación: | 2015 | Editor: | American Chemical Society | Citación: | Journal of Medicinal Chemistry 58: 6704-6709 (2015) | Resumen: | This study describes CholesteroNitrone 2 as an antioxidant and neuroprotective agent against ischemic injury. Neuroprotection was assessed using in vitro and in vivo experimental ischemia models. The compound significantly increased cell viability, induced neuroprotection following ischemic reperfusion, and decreased neurological deficit scores in treated animals, supporting the next preclinical studies as a potential agent for the treatment of stroke. (Figure Presented). | Versión del editor: | http://dx.doi.org/10.1021/acs.jmedchem.5b00755 | URI: | http://hdl.handle.net/10261/126648 | DOI: | 10.1021/acs.jmedchem.5b00755 | Identificadores: | doi: 10.1021/acs.jmedchem.5b00755 issn: 0022-2623 e-issn: 1520-4804 |
| Aparece en las colecciones: | (IQM) Artículos (IQOG) Artículos |
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| accesoRestringido.pdf | 15,38 kB | Adobe PDF |  Visualizar/Abrir |
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