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Title

CholesteroNitrones for Stroke

AuthorsAyuso, M. I.; Chioua, Mourad ; Martínez-Alonso, E.; Soriano, Elena ; Montaner, Joan; Masjuán, J.; Hadjipavlou-Litina, Dimitra; Marco-Contelles, José ; Alcázar, Alberto
Issue Date2015
PublisherAmerican Chemical Society
CitationJournal of Medicinal Chemistry 58: 6704-6709 (2015)
AbstractThis study describes CholesteroNitrone 2 as an antioxidant and neuroprotective agent against ischemic injury. Neuroprotection was assessed using in vitro and in vivo experimental ischemia models. The compound significantly increased cell viability, induced neuroprotection following ischemic reperfusion, and decreased neurological deficit scores in treated animals, supporting the next preclinical studies as a potential agent for the treatment of stroke. (Figure Presented).
Publisher version (URL)http://dx.doi.org/10.1021/acs.jmedchem.5b00755
URIhttp://hdl.handle.net/10261/126648
DOI10.1021/acs.jmedchem.5b00755
Identifiersdoi: 10.1021/acs.jmedchem.5b00755
issn: 0022-2623
e-issn: 1520-4804
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