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dc.contributor.authorAlagia, Adelees_ES
dc.contributor.authorTerrazas, Montserrates_ES
dc.contributor.authorEritja Casadellà, Ramónes_ES
dc.date.accessioned2015-12-07T09:23:07Z-
dc.date.available2015-12-07T09:23:07Z-
dc.date.issued2015-
dc.identifier.citationRNA & DISEASEes_ES
dc.identifier.urihttp://hdl.handle.net/10261/126536-
dc.description.abstractUpon the discovery of the RNA interference pathway, the development of nucleic acids derivatives for therapeutic purposes has soon caught the attention of biomedical researchers. Although synthetic small interfering RNA (siRNA) has been extensively used to downregulate any protein-coding mRNA, several key issues still remain unsolved. The acyclic threoninol nucleic acid (aTNA), placed at certain siRNA positions, is a useful modification to reduce the oligonucleotides vulnerability towards nucleases. In addition, it can be exploited to avoid several OFF-target effects that limit the biological safety of the RNAi-based agents.es_ES
dc.description.sponsorshipWe thank the European Union (NMP4-LA-2011-262943, MULTIFUN), the Spanish MINECO (CTQ2014-52588-R and CTQ2014-61758-EXP), and the Generalitat de Catalunya for funding this research. CIBER-BBN is financed by the European Regional Development Fund and the Instituto de Salud Carlos III through an initiative funded during the VI Plan Nacional 2008-2011, the Ingenio 2010, the Consolider Program, and the CIBER Action.es_ES
dc.language.isoenges_ES
dc.publisherSmart Science and Technologyes_ES
dc.relation.isversionofPublisher's versiones_ES
dc.rightsopenAccesses_ES
dc.subjectRNA interferencees_ES
dc.subjectsIRNASes_ES
dc.subjectacyclic nucleic acidses_ES
dc.titleRNA modified with acyclic threoninol nucleic acids for RNA interferencees_ES
dc.typeartículoes_ES
dc.identifier.doihttp://dx.doi.org/10.14800/rd.907-
dc.description.peerreviewedPeer reviewedes_ES
dc.relation.publisherversionDOI: http://dx.doi.org/10.14800/rd.907es_ES
dc.rights.licensehttp://www.sherpa.ac.uk/romeo/issn/2375-2467/es_ES
dc.relation.csices_ES
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