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RNA modified with acyclic threoninol nucleic acids for RNA interference

AuthorsAlagia, Adele ; Terrazas, Montserrat ; Eritja Casadellà, Ramón
KeywordsRNA interference
acyclic nucleic acids
Issue Date2015
PublisherSmart Science and Technology
AbstractUpon the discovery of the RNA interference pathway, the development of nucleic acids derivatives for therapeutic purposes has soon caught the attention of biomedical researchers. Although synthetic small interfering RNA (siRNA) has been extensively used to downregulate any protein-coding mRNA, several key issues still remain unsolved. The acyclic threoninol nucleic acid (aTNA), placed at certain siRNA positions, is a useful modification to reduce the oligonucleotides vulnerability towards nucleases. In addition, it can be exploited to avoid several OFF-target effects that limit the biological safety of the RNAi-based agents.
Publisher version (URL)DOI: http://dx.doi.org/10.14800/rd.907
Appears in Collections:(IQAC) Artículos
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