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dc.contributor.authorBenabou, Sanaees_ES
dc.contributor.authorAviñó, Annaes_ES
dc.contributor.authorGonzález, Carloses_ES
dc.contributor.authorEritja Casadellà, Ramónes_ES
dc.contributor.authorGargallo, Raimundoes_ES
dc.date.accessioned2015-12-04T07:46:11Z-
dc.date.available2015-12-04T07:46:11Z-
dc.date.issued2014-
dc.identifier.citationRSC Advances 4: 26956-26980 (2014)es_ES
dc.identifier.urihttp://hdl.handle.net/10261/126489-
dc.description.abstractThe i-motif structure is formed in cytosine-rich sequences, its building block being the cytosine·cytosine + base pair. This structure is particularly stable at pH values below physiological (∼7.4) and, because of that, it has not attracted as much biological interest as other non-canonical structures such as the G-quadruplex. Nowadays, the proposal of potential roles in vivo, as well as nanotechnological applications, has produced an increasing interest in its study. In this context, the present work provides an overall picture of the i-motif structure. Those aspects related to formation and stability, such as chemical modifications or the interaction with ligands, are discussed. Special attention has been made to the i-motif structures that could have a hypothetical role in vivo, such as those present near the promoter region of several oncogenes.es_ES
dc.description.sponsorshipWe acknowledge funding from the Spanish government (CTQ2012-38616-C02-02 and CTQ-2010-20541-C03). Sanae Benabou thanks the Spanish Ministerio de Economía y Competitividad for a PhD grant.es_ES
dc.language.isoenges_ES
dc.publisherRoyal Society of Chemistry (UK)es_ES
dc.relation.isversionofPostprintes_ES
dc.rightsopenAccesses_ES
dc.subjectChemical stabilityes_ES
dc.subjectNucleic acidses_ES
dc.subjectOncogenic viruseses_ES
dc.subjectBase pairses_ES
dc.subjectBuilding blockeses_ES
dc.subjectph valuees_ES
dc.subjectG-quadruplexeses_ES
dc.subjectpromoter regiones_ES
dc.subjectI-motifes_ES
dc.subjectIn-vivoes_ES
dc.subjectChemical modificationes_ES
dc.titleFundamental aspects of the nucleic acid i-motif structureses_ES
dc.typeartículoes_ES
dc.identifier.doihttp://dx.doi.org/10.1039/c4ra02129k-
dc.description.peerreviewedPeer reviewedes_ES
dc.relation.publisherversionhttp://doi.org/10.1039/c4ra02129kes_ES
dc.identifier.e-issn2046-2069-
dc.rights.licensehttp://www.sherpa.ac.uk/romeo/issn/2046-2069/es_ES
dc.relation.csices_ES
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