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dc.contributor.authorOrtiz, Miguel A.es_ES
dc.contributor.authorNúñez, Concepciónes_ES
dc.contributor.authorOrdóñez, Davides_ES
dc.contributor.authorÁlvarez-Cermeño, José C.es_ES
dc.contributor.authorMartínez-Rodriguez, José E.es_ES
dc.contributor.authorSánchez, Antonio J.es_ES
dc.contributor.authorArroyo, Rafaeles_ES
dc.contributor.authorIzquierdo, Guillermoes_ES
dc.contributor.authorMalhotra, Sunnyes_ES
dc.contributor.authorMontalbán, X.es_ES
dc.contributor.authorGarcía-Merino, Antonioes_ES
dc.contributor.authorMunteis, Elviraes_ES
dc.contributor.authorAlcina, Antonioes_ES
dc.contributor.authorComabella, Manueles_ES
dc.contributor.authorMatesanz, F.es_ES
dc.contributor.authorVillar, Luisa M.es_ES
dc.contributor.authorUrcelay, Elenaes_ES
dc.date.accessioned2015-12-03T11:56:50Z-
dc.date.available2015-12-03T11:56:50Z-
dc.date.issued2015-08-14-
dc.identifier.citationPLoS ONEes_ES
dc.identifier.urihttp://hdl.handle.net/10261/126466-
dc.description.abstractMultiple sclerosis (MS) is a neurodegenerative, autoimmune disease of the central nervous system. Genome-wide association studies (GWAS) have identified over hundred polymorphisms with modest individual effects in MS susceptibility and they have confirmed the main individual effect of the Major Histocompatibility Complex. Additional risk loci with immunologically relevant genes were found significantly overrepresented. Nonetheless, it is accepted that most of the genetic architecture underlying susceptibility to the disease remains to be defined. Candidate association studies of the leukocyte immunoglobulin-like receptor LILRA3 gene in MS have been repeatedly reported with inconsistent results. Objectives In an attempt to shed some light on these controversial findings, a combined analysis was performed including the previously published datasets and three newly genotyped cohorts. Both wild-type and deleted LILRA3 alleles were discriminated in a single-tube PCR amplification and the resulting products were visualized by their different electrophoretic mobilities. Results and Conclusion Overall, this meta-analysis involved 3200 MS patients and 3069 matched healthy controls and it did not evidence significant association of the LILRA3 deletion [carriers of LILRA3 deletion: p = 0.25, OR (95% CI) = 1.07 (0.95–1.19)], even after stratification by gender and the HLA-DRB1*15:01 risk allele.es_ES
dc.language.isoenges_ES
dc.publisherPublic Library of Sciencees_ES
dc.relation.isversionofPublisher's versiones_ES
dc.rightsopenAccesses_ES
dc.titleInfluence of the LILRA3 Deletion on Multiple Sclerosis Risk: Original Data and Meta- Analysises_ES
dc.typeartículoes_ES
dc.identifier.doi10.1371/journal.pone.0134414-
dc.description.peerreviewedPeer reviewedes_ES
dc.relation.publisherversionhttp://dx.doi.org/10.1371/journal.pone.0134414es_ES
dc.identifier.e-issn1932-6203-
dc.rights.licensehttp://creativecommons.org/licenses/by/4.0/es_ES
dc.contributor.funderInstituto de Salud Carlos IIIes_ES
dc.contributor.funderInstituto de Salud Carlos IIIes_ES
dc.contributor.funderEuropean Commissiones_ES
dc.contributor.funderJunta de Andalucíaes_ES
dc.relation.csices_ES
dc.identifier.funderhttp://dx.doi.org/10.13039/501100004587es_ES
dc.identifier.funderhttp://dx.doi.org/10.13039/501100000780es_ES
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