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Bioactive triterpene derivatives from latex of two Euphorbia species

AuthorsMazoir, Noureddine; Benharref, Ahmed; Bailén, María; Reina, Matías ; González-Coloma, Azucena
Insect growth regulation
Spodoptera littoralis
Issue Date4-Mar-2008
CitationPhytochemistry 69(6): 1328-1338 (2008)
AbstractWe have investigated the antifeedant and toxic effects of 23 semisynthetic terpenoid derivatives obtained through chemical modifications of the major components of Euphorbia resinifera (α-euphol and α-euphorbol) and E. officinarum (obtusifoliol and 31-norlanostenol) latex on several insect species (Spodoptera littoralis, Myzus persicae and Rhopalosiphum padi), their selective cytotoxicity on insect Sf9 and mammalian CHO cells and their phytotoxic effects on Lactuca sativa. The conversions focused mainly on positions 3, 7, 11, and 24 with several oxidizing agents. A total of 18 compounds affected S. littoralis growth (IGR). Our results support the importance of the C-3 substituent, suggest the involvement of the C-7 substituent and indicate that the C-3 hydroxyl is not essential for the IGR effect. Overall, Sf9 cells were more sensitive to the active compounds than CHO cells. All of these compounds had non selective moderate phytotoxic effects on radicle elongation of L. sativa.
Description11 pages, 1 figure, 1 table, 2 schemes.-- PMID: 18304594 [PubMed].-- Printed version published Apr 2008.
Publisher version (URL)http://dx.doi.org/10.1016/j.phytochem.2008.01.004
Appears in Collections:(IPNA) Artículos
(ICA) Artículos
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