English   español  
Por favor, use este identificador para citar o enlazar a este item: http://hdl.handle.net/10261/125643
COMPARTIR / IMPACTO:
Estadísticas
logo share SHARE   Add this article to your Mendeley library MendeleyBASE
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:
Título

Beneficial effects of oxyntomodulin in the treatment of hepatic regeneration in non alcoholic fatty liver disease

AutorValdecantos, M. P.; Pardo, Virginia; Álvarez, Carmen; Grimsby, J.; Rondinone, Cristina M.; Valverde, Ángela M.
Fecha de publicación2014
CitaciónCNIC Conference: Energy homeostasis and metabolic disease (2014)
Resumen[Objectives]: Partial hepatectomy (PH) is a common surgical intervention to treat liver diseases, particularly hepatocellular carcinoma. Since, a number of epidemiologic and clinical studies have shown a close association between non-alcoholic fatty liver disease (NAFLD) and response to PH, we designed a pharmacological intervention protocol with a PEGylated derivated of oxyntomodulyn aimed to investigate the effect of this drug on hepatic regeneration in a NAFLD model. [Methods]: 8 week-old male mice on the C57BU6 background were divided in 4 groups. Groups 1 and 2 were maintained on a chow diet (CHD) and groups 3 and 4 were fed with choline-methionine-deficient (MCD) diet. After 1 week, groups 2 and 4 were injected (S.C.) with oxyntomodulyn at 4 mg/kg every 2 days. Then, PH was performed and mice were maintained with the same diet and pharmacological intervention until they were sacrificed at several time-periods. Parameters that assess liver function and hepatic regeneration were analyzed. [Results]:S urvival rate following PW was increased with oxyntomodulyn in both dietary groups. Higher rate of DNA synthesis was found in the CHD and MCD oxyntomodulyn treated animals after 48 h post-PH. Hepatic regeneration index, analyzed 2 weeks after PH, was significantly improved in mice receiving CHD or MCD diet plus oxyntomodulyn as compared with not treated animals. In addition, oxyntomodulyn treatment was associated with decreased transaminase levels and improved liver histology in mice to receiving MCD diet. Moreover, several parameters that assessed hepatic inflammation, oxidative stress, fibrosis and apoptosis were increased by the MCD diet and ameliorated by oxyntomodulyn treatment. [Conclusions]: Taken together, these results strongly suggest a novel role of an oxyntomodulin-like dual acting GLPl R and GCGR co-agonist in alleviating NASH, improving liver regeneration following PH and may offer a potential therapeutic application in patients with NASH.
DescripciónResumen del póster presentado a la Conferencia del Centro Nacional de Investigaciones Cardiovasculares (CNIC) titulada: "Energy homeostasis and metabolic disease", celebrada en Madrid del 7 al 8 de noviembre de 2014.
URIhttp://hdl.handle.net/10261/125643
Aparece en las colecciones: (IIBM) Comunicaciones congresos
Ficheros en este ítem:
Fichero Descripción Tamaño Formato  
accesoRestringido.pdf15,38 kBAdobe PDFVista previa
Visualizar/Abrir
Mostrar el registro completo
 


NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.