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Determination of interleukin-1α in human NCTC 2544 keratinocyte cells as a predictor of skin irritation from lysine-based surfactants

AutorSánchez, Lourdes; Mitjans, Montserrat; Infante, María Rosa; Vinardell, M. Pilar
Palabras claveLysine-based surfactant
Skin irritation
Fecha de publicación1-nov-2006
CitaciónToxicology Letters 167(1):40-46 (2006)
ResumenLysine derivative surfactants are a class of amino acid-based surfactants synthesized as lecithin analogues that deserve particular attention because of their low toxicity and high biocompatibility. To complete the toxicological profile of these surfactants, IL-1α production (cell-associated and release to the culture medium) was determined as an in vitro method for predicting skin irritation. In addition, an MTT assay was used as a viability marker in keratinocytes NCTC 2544. Keratinocytes are a biologically relevant target for developing in vitro techniques to assess skin irritants: moreover, they are the principal source of the proinflammatory cytokine IL-1α in the epidermis. Lysine derivatives proved to be less potent in stimulating IL-1α synthesis and induced a lower release of this cytokine into the culture medium when compared to the anionic surfactant sodium dodecyl sulfate. Due to their low irritancy potential, lysine-based surfactants may offer promising applications in pharmaceutical and cosmetic preparations
Descripción7 pages, 1 table, 3 figures.
Versión del editorhttp://dx.doi.org/10.1016/j.toxlet.2006.08.006
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