Por favor, use este identificador para citar o enlazar a este item:
http://hdl.handle.net/10261/125471
COMPARTIR / EXPORTAR:
SHARE CORE BASE | |
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
Campo DC | Valor | Lengua/Idioma |
---|---|---|
dc.contributor.author | Chamorro, Susana | - |
dc.contributor.author | Gutiérrez, Lucía | - |
dc.contributor.author | Vaquero, M. Pilar | - |
dc.contributor.author | Verdoy, D. | - |
dc.contributor.author | Salas, Y | - |
dc.contributor.author | Luengo, Yurena | - |
dc.contributor.author | Brenes, Agustín | - |
dc.contributor.author | Terán, F. J. | - |
dc.date.accessioned | 2015-11-23T10:40:21Z | - |
dc.date.available | 2015-11-23T10:40:21Z | - |
dc.date.issued | 2015 | - |
dc.identifier | doi: 10.1088/0957-4484/26/20/205101 | - |
dc.identifier | issn: 1361-6528 | - |
dc.identifier.citation | Nanotechnology 26 (2015) | - |
dc.identifier.uri | http://hdl.handle.net/10261/125471 | - |
dc.description.abstract | Iron oxide nanoparticles with engineered physical and biochemical properties are finding a rapidly increasing number of biomedical applications. However, a wide variety of safety concerns, especially those related to oral exposure, still need to be addressed for iron oxide nanoparticles in order to reach clinical practice. Here, we report on the effects of chronic oral exposure to low doses of γ-Fe2O3 nanoparticles in growing chickens. Animal observation, weight, and diet intake reveal no adverse signs, symptoms, or mortality. No nanoparticle accumulation was observed in liver, spleen, and duodenum, with feces as the main excretion route. Liver iron level and duodenal villi morphology reflect the bioavailability of the iron released from the partial transformation of γ-Fe2O3 nanoparticles in the acid gastric environment. Duodenal gene expression studies related to the absorption of iron from γ-Fe2O3 nanoparticles indicate the enhancement of a ferric over ferrous pathway supporting the role of mucins. Our findings reveal that oral administration of iron oxide nanoparticles is a safe route for drug delivery at low nanoparticle doses. | - |
dc.publisher | Institute of Physics Publishing | - |
dc.rights | openAccess | en_EN |
dc.title | Safety assessment of chronic oral exposure to iron oxide nanoparticles | - |
dc.type | artículo | - |
dc.identifier.doi | 10.1088/0957-4484/26/20/205101 | - |
dc.date.updated | 2015-11-23T10:40:22Z | - |
dc.description.version | Peer Reviewed | - |
dc.language.rfc3066 | eng | - |
dc.relation.csic | Sí | - |
dc.type.coar | http://purl.org/coar/resource_type/c_6501 | es_ES |
item.fulltext | With Fulltext | - |
item.grantfulltext | open | - |
item.cerifentitytype | Publications | - |
item.openairetype | artículo | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
Aparece en las colecciones: | (ICTAN) Artículos |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
---|---|---|---|---|
Safety_assesment.pdf | 449,83 kB | Adobe PDF | Visualizar/Abrir |
CORE Recommender
SCOPUSTM
Citations
49
checked on 21-abr-2024
WEB OF SCIENCETM
Citations
44
checked on 22-feb-2024
Page view(s)
306
checked on 24-abr-2024
Download(s)
617
checked on 24-abr-2024
Google ScholarTM
Check
Altmetric
Altmetric
NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.