Por favor, use este identificador para citar o enlazar a este item:
http://hdl.handle.net/10261/125375
COMPARTIR / EXPORTAR:
SHARE CORE BASE | |
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
Campo DC | Valor | Lengua/Idioma |
---|---|---|
dc.contributor.author | Pérez-Rentero, Sonia | es_ES |
dc.contributor.author | Somoza, Álvaro | es_ES |
dc.contributor.author | Grijalvo, Santiago | es_ES |
dc.contributor.author | Janoušek, Jiří | es_ES |
dc.contributor.author | Bělohradský, Martin | es_ES |
dc.contributor.author | Stará̈, Irena G. | es_ES |
dc.contributor.author | Starý, Ivo | es_ES |
dc.contributor.author | Eritja Casadellà, Ramón | es_ES |
dc.date.accessioned | 2015-11-20T08:16:11Z | - |
dc.date.available | 2015-11-20T08:16:11Z | - |
dc.date.issued | 2013 | - |
dc.identifier.citation | Journal of Chemistry | es_ES |
dc.identifier.uri | http://hdl.handle.net/10261/125375 | - |
dc.description.abstract | Oligonucleotide conjugates carrying a single functionalized tetrathiafulvalene (TTF) unit linked through a threoninol molecule to the 3′ or 5′ ends were synthesized together with their complementary oligonucleotides carrying a TTF, pyrene, or pentafluorophenyl group. TTF-oligonucleotide conjugates formed duplexes with higher thermal stability than the corresponding unmodified oligonucleotides and pyrene- and pentafluorophenyl-modified oligonucleotides. TTF-modified oligonucleotides are able to bind to citrate-stabilized gold nanoparticles (AuNPs) and produce stable gold AuNPs functionalized with oligonucleotides. Finally, TTF- oligoribonucleotides have been synthesized to produce siRNA duplexes carrying TTF units. The presence of the TTF molecule is compatible with the RNA interference mechanism for gene inhibition. | es_ES |
dc.description.sponsorship | The authors thank Dr. Anna Avi˜n´o for providing the nonmodified oligonucleotides 11–14.This researchwas supported by the European Commission (Grants FP7-FUNMOL 213382 and NMP4-LA-2011-262943, MULTIFUN), by the Spanish Ministry of Education (grant CTQ2010-20541, SAF2010-15440), the Generalitat de Catalunya (2009/SGR/208), the Czech Science Foundation (P207/10/2214), the Ministry of Education, Youth and Sports of the Czech Republic (7E09054), and the Institute of Organic Chemistry and Biochemistry AS CR (RVO: 61388963). The authors declare no conflict of interests. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Hindawi Publishing Corporation | es_ES |
dc.relation | FP7-FUNMOL 213382; EC | es_ES |
dc.relation.isversionof | Publisher's version | es_ES |
dc.rights | openAccess | es_ES |
dc.subject | Oligonucleotides | es_ES |
dc.subject | RNA | es_ES |
dc.subject | TTF | es_ES |
dc.subject | siRNA | es_ES |
dc.title | Biophysical and RNA interference inhibitory properties of oligonucleotides carrying tetrathiafulvalene groups at terminal positions | es_ES |
dc.type | artículo | es_ES |
dc.identifier.doi | 10.1155/2013/650610 | - |
dc.description.peerreviewed | Peer reviewed | es_ES |
dc.relation.publisherversion | DOI: 10.1155/2013/650610 | es_ES |
dc.rights.license | http://www.sherpa.ac.uk/romeo/issn/2090-9063/ | es_ES |
dc.contributor.funder | European Commission | es_ES |
dc.relation.csic | Sí | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100000780 | es_ES |
dc.type.coar | http://purl.org/coar/resource_type/c_6501 | es_ES |
item.openairetype | artículo | - |
item.cerifentitytype | Publications | - |
item.languageiso639-1 | en | - |
item.grantfulltext | open | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.fulltext | With Fulltext | - |
Aparece en las colecciones: | (IQAC) Artículos |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
---|---|---|---|---|
JChem2013_TTF_650610.pdf | Artículo principal | 3,57 MB | Adobe PDF | Visualizar/Abrir |
CORE Recommender
SCOPUSTM
Citations
3
checked on 27-mar-2024
WEB OF SCIENCETM
Citations
3
checked on 24-feb-2024
Page view(s)
278
checked on 27-mar-2024
Download(s)
238
checked on 27-mar-2024
Google ScholarTM
Check
Altmetric
Altmetric
NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.