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dc.contributor.authorPérez-Rentero, Soniaes_ES
dc.contributor.authorSomoza, Álvaroes_ES
dc.contributor.authorGrijalvo, Santiagoes_ES
dc.contributor.authorJanoušek, Jiříes_ES
dc.contributor.authorBělohradský, Martines_ES
dc.contributor.authorStará̈, Irena G.es_ES
dc.contributor.authorStarý, Ivoes_ES
dc.contributor.authorEritja Casadellà, Ramónes_ES
dc.date.accessioned2015-11-20T08:16:11Z-
dc.date.available2015-11-20T08:16:11Z-
dc.date.issued2013-
dc.identifier.citationJournal of Chemistryes_ES
dc.identifier.urihttp://hdl.handle.net/10261/125375-
dc.description.abstractOligonucleotide conjugates carrying a single functionalized tetrathiafulvalene (TTF) unit linked through a threoninol molecule to the 3′ or 5′ ends were synthesized together with their complementary oligonucleotides carrying a TTF, pyrene, or pentafluorophenyl group. TTF-oligonucleotide conjugates formed duplexes with higher thermal stability than the corresponding unmodified oligonucleotides and pyrene- and pentafluorophenyl-modified oligonucleotides. TTF-modified oligonucleotides are able to bind to citrate-stabilized gold nanoparticles (AuNPs) and produce stable gold AuNPs functionalized with oligonucleotides. Finally, TTF- oligoribonucleotides have been synthesized to produce siRNA duplexes carrying TTF units. The presence of the TTF molecule is compatible with the RNA interference mechanism for gene inhibition.es_ES
dc.description.sponsorshipThe authors thank Dr. Anna Avi˜n´o for providing the nonmodified oligonucleotides 11–14.This researchwas supported by the European Commission (Grants FP7-FUNMOL 213382 and NMP4-LA-2011-262943, MULTIFUN), by the Spanish Ministry of Education (grant CTQ2010-20541, SAF2010-15440), the Generalitat de Catalunya (2009/SGR/208), the Czech Science Foundation (P207/10/2214), the Ministry of Education, Youth and Sports of the Czech Republic (7E09054), and the Institute of Organic Chemistry and Biochemistry AS CR (RVO: 61388963). The authors declare no conflict of interests.es_ES
dc.language.isoenges_ES
dc.publisherHindawi Publishing Corporationes_ES
dc.relationFP7-FUNMOL 213382; ECes_ES
dc.relation.isversionofPublisher's versiones_ES
dc.rightsopenAccesses_ES
dc.subjectOligonucleotideses_ES
dc.subjectRNAes_ES
dc.subjectTTFes_ES
dc.subjectsiRNAes_ES
dc.titleBiophysical and RNA interference inhibitory properties of oligonucleotides carrying tetrathiafulvalene groups at terminal positionses_ES
dc.typeartículoes_ES
dc.identifier.doi10.1155/2013/650610-
dc.description.peerreviewedPeer reviewedes_ES
dc.relation.publisherversionDOI: 10.1155/2013/650610es_ES
dc.rights.licensehttp://www.sherpa.ac.uk/romeo/issn/2090-9063/es_ES
dc.contributor.funderEuropean Commissiones_ES
dc.relation.csices_ES
dc.identifier.funderhttp://dx.doi.org/10.13039/501100000780es_ES
dc.type.coarhttp://purl.org/coar/resource_type/c_6501es_ES
item.openairetypeartículo-
item.cerifentitytypePublications-
item.languageiso639-1en-
item.grantfulltextopen-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.fulltextWith Fulltext-
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