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Biophysical and RNA interference inhibitory properties of oligonucleotides carrying tetrathiafulvalene groups at terminal positions

AuthorsPérez-Rentero, Sonia; Somoza, Álvaro; Grijalvo, Santiago CSIC ORCID; Janoušek, Jiří; Bělohradský, Martin; Stará̈, Irena G.; Starý, Ivo; Eritja Casadellà, Ramón CSIC ORCID
Issue Date2013
PublisherHindawi Publishing Corporation
CitationJournal of Chemistry
AbstractOligonucleotide conjugates carrying a single functionalized tetrathiafulvalene (TTF) unit linked through a threoninol molecule to the 3′ or 5′ ends were synthesized together with their complementary oligonucleotides carrying a TTF, pyrene, or pentafluorophenyl group. TTF-oligonucleotide conjugates formed duplexes with higher thermal stability than the corresponding unmodified oligonucleotides and pyrene- and pentafluorophenyl-modified oligonucleotides. TTF-modified oligonucleotides are able to bind to citrate-stabilized gold nanoparticles (AuNPs) and produce stable gold AuNPs functionalized with oligonucleotides. Finally, TTF- oligoribonucleotides have been synthesized to produce siRNA duplexes carrying TTF units. The presence of the TTF molecule is compatible with the RNA interference mechanism for gene inhibition.
Publisher version (URL)DOI: 10.1155/2013/650610
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