English   español  
Por favor, use este identificador para citar o enlazar a este item: http://hdl.handle.net/10261/125375
Compartir / Impacto:
Estadísticas
Add this article to your Mendeley library MendeleyBASE
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Título

Biophysical and RNA interference inhibitory properties of oligonucleotides carrying tetrathiafulvalene groups at terminal positions

AutorPérez-Rentero, Sonia; Somoza, Álvaro; Grijalvo, Santiago; Janoušek, Jiří; Bělohradský, Martin; Stará̈, Irena G.; Starý, Ivo; Eritja Casadellà, Ramón
Palabras claveOligonucleotides
RNA
TTF
siRNA
Fecha de publicación2013
EditorHindawi Publishing Corporation
CitaciónJournal of Chemistry
ResumenOligonucleotide conjugates carrying a single functionalized tetrathiafulvalene (TTF) unit linked through a threoninol molecule to the 3′ or 5′ ends were synthesized together with their complementary oligonucleotides carrying a TTF, pyrene, or pentafluorophenyl group. TTF-oligonucleotide conjugates formed duplexes with higher thermal stability than the corresponding unmodified oligonucleotides and pyrene- and pentafluorophenyl-modified oligonucleotides. TTF-modified oligonucleotides are able to bind to citrate-stabilized gold nanoparticles (AuNPs) and produce stable gold AuNPs functionalized with oligonucleotides. Finally, TTF- oligoribonucleotides have been synthesized to produce siRNA duplexes carrying TTF units. The presence of the TTF molecule is compatible with the RNA interference mechanism for gene inhibition.
Versión del editorDOI: 10.1155/2013/650610
URIhttp://hdl.handle.net/10261/125375
DOI10.1155/2013/650610
Aparece en las colecciones: (IQAC) Artículos
Ficheros en este ítem:
Fichero Descripción Tamaño Formato  
JChem2013_TTF_650610.pdfArtículo principal3,57 MBAdobe PDFVista previa
Visualizar/Abrir
Mostrar el registro completo
 

Artículos relacionados:


NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.