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Título: | Synthesis, RNAi activity and nuclease-resistant properties of apolar carbohydrates siRNA conjugates |
Autor: | Vengut-Climent, Empar; Terrazas, Montserrat CSIC ORCID; Lucas, Ricardo CSIC; Arévalo-Ruiz, Matilde; Eritja Casadellà, Ramón CSIC ORCID ; Morales, Juan Carlos CSIC ORCID | Palabras clave: | Carbohydrates RNA Lipophilic vector siRNA Modified siRNA Phosphoramidite |
Fecha de publicación: | jul-2013 | Editor: | Elsevier | Citación: | Bioorganic and Medicinal Chemistry Letters | Resumen: | Oligoribonucleotide conjugates carrying apolar carbohydrates at the 5′-end and the corresponding siRNA duplexes have been prepared using phosphoramidite chemistry. All the carbohydrate-siRNA derivatives were compatible with RNA interference machinery if transfected with oligofectamine. In the absence of a transfection agent, some of them exerted certain reduction of gene expression. Double-tailed permethylated glucose conjugated to siRNA through a long spacer inhibited gene expression up to 26% compared to the scrambled duplex. Such modifications contribute positively to the stability of oligoribonucleotides against 5′-exonuclease degradation. | Versión del editor: | DOI: 10.1016/j.bmcl.2013.05.065 | URI: | http://hdl.handle.net/10261/125374 | DOI: | 10.1016/j.bmcl.2013.05.065 |
Aparece en las colecciones: | (IQAC) Artículos |
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BMCL2013.pdf | Artículo principal | 431,69 kB | Adobe PDF | Visualizar/Abrir |
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