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dc.contributor.authorLindsay, Ken J.-
dc.contributor.authorDu, Jianhai-
dc.contributor.authorSloat, Stephanie R.-
dc.contributor.authorContreras, Laura-
dc.contributor.authorLinton, Jonathan-
dc.contributor.authorTurner, Sally J.-
dc.contributor.authorSadilek, Martin-
dc.contributor.authorSatrústegui, Jorgina-
dc.contributor.authorHurley, James B.-
dc.date.accessioned2015-11-19T11:54:01Z-
dc.date.available2015-11-19T11:54:01Z-
dc.date.issued2014-07-02-
dc.identifierdoi: 101073-
dc.identifierissn: 0027-8424-
dc.identifier.citationPROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 111: 15579- 15584 (2014)-
dc.identifier.urihttp://hdl.handle.net/10261/125354-
dc.description.abstractSymbiotic relationships between neurons and glia must adapt to structures, functions, and metabolic roles of the tissues they are in. We show here that Müller glia in retinas have specific enzyme deficiencies that can enhance their ability to synthesize Gln. The metabolic cost of these deficiencies is that they impair the Müller cell’s ability to metabolize Glc. We show here that the cells can compensate for this deficiency by using metabolites produced by neurons. Müller glia are deficient for pyruvate kinase (PK) and for aspartate/glutamate carrier 1 (AGC1), a key component of the malate-aspartate shuttle. In contrast, photoreceptor neurons express AGC1 and the M2 isoform of pyruvate kinase, which is commonly associated with aerobic glycolysis in tumors, proliferating cells, and some other cell types. Our findings reveal a previously unidentified type of metabolic relationship between neurons and glia. Müller glia compensate for their unique metabolic adaptations by using lactate and aspartate from neurons as surrogates for their missing PK and AGC1.-
dc.description.sponsorshipThis work was supported by National Eye Institute Grants EY06641 and EY023346 (to J.B.H.), by Vision Core Grant EY1730 and Grants BFU2011-30456-C02-01/BMC and S2010/BMD-2402 (to J.S.), and by the Fundación Ramón Areces to the Centro de Biología Molecular Severo Ochoa-
dc.publisherNational Academy of Sciences (U.S.)-
dc.relation.isversionofPublisher's version-
dc.rightsopenAccess-
dc.titlePyruvate kinase and aspartate-glutamate carrier distributions reveal key metabolic links between neurons and glia in retina.-
dc.typeartículo-
dc.identifier.doi101073-
dc.date.updated2015-11-19T11:54:01Z-
dc.description.versionPeer Reviewed-
dc.language.rfc3066eng-
dc.contributor.funderFundación Ramón Areces-
dc.contributor.funderCSIC-UAM - Centro de Biología Molecular Severo Ochoa (CBM)-
dc.contributor.funderNational Eye Institute (US)-
dc.relation.csic-
dc.identifier.funderhttp://dx.doi.org/10.13039/100008054es_ES
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