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dc.contributor.authorFerreira, Rubénes_ES
dc.contributor.authorAviñó, Annaes_ES
dc.contributor.authorMazzini, Stefaniaes_ES
dc.contributor.authorEritja Casadellà, Ramónes_ES
dc.date.accessioned2015-11-19T08:48:38Z-
dc.date.available2015-11-19T08:48:38Z-
dc.date.issued2012-06-
dc.identifier.citationMoleculeses_ES
dc.identifier.urihttp://hdl.handle.net/10261/125326-
dc.description.abstractSeveral acridine derivatives were synthesized and their anti-proliferative activity was determined. The most active molecules were derivatives of 5-methylacridine-4-carboxylic acid. The DNA binding properties of the synthesized acridines were analyzed by competitive dialysis and compared with the anti-proliferative activities. While inactive acridine derivatives showed high selectivity for G-quadruplex structures, the most active 5-methylacridine-4-carboxamide derivatives had high affinity for DNA but showed poor specificity. An NMR titration study was performed with the most active 5-methylacridine-4-carboxamide, confirming the high affinity of this compound for both duplex and quadruplex DNAs.es_ES
dc.description.sponsorshipThis work was supported by the Spanish Ministry of Education (grants BFU2007-63287, CTQ2010-20541-C03-01), and the Generalitat de Catalunya (2009/SGR/208). CIBER-BBN is an initiative funded by the VI National R&D&i Plan 2008-2011, Iniciativa Ingenio 2010, Consolider Program, CIBER Actions and financed by the Instituto de Salud Carlos III with assistance from the European Regional Development Fund. SM acknowledges the support of the University of Milano (PUR 2009 Funds) and PRIN09 (2009Prot.2009J54YAP_005). RF is recipient of a FPI contract from the Spanish Ministry of Science.es_ES
dc.description.sponsorshipWe acknowledge support by the CSIC Open Access Publication Initiative through its Unit of Information Resources for Research (URICI).-
dc.language.isoenges_ES
dc.publisherMultidisciplinary Digital Publishing Institutees_ES
dc.relation.isversionofPublisher's versiones_ES
dc.rightsopenAccess-
dc.subjectDNA-binding drugses_ES
dc.subjectNMRes_ES
dc.subjectAcridinees_ES
dc.subjectG-quadruplexes_ES
dc.subjectSolid-phase synthesises_ES
dc.subjectDNAes_ES
dc.titleSynthesis, DNA-binding and antiproliferative properties of acridine and 5-methylacridine derivativeses_ES
dc.typeartículo-
dc.identifier.doihttp://dx.doi.org/10.3390/molecules17067067-
dc.description.peerreviewedPeer reviewedes_ES
dc.relation.publisherversionhttp://doi.org/10.3390/molecules17067067es_ES
dc.rights.licensehttp://creativecommons.org/licenses/by/3.0/).es_ES
dc.contributor.funderConsejo Superior de Investigaciones Científicas (España)-
dc.contributor.funderMinisterio de Educación (España)-
dc.contributor.funderGeneralitat de Catalunya-
dc.contributor.funderInstituto de Salud Carlos III-
dc.contributor.funderEuropean Commission-
dc.contributor.funderUniversità degli Studi di Milano-
dc.relation.csices_ES
dc.identifier.funderhttp://dx.doi.org/10.13039/501100003339es_ES
dc.identifier.funderhttp://dx.doi.org/10.13039/501100004587es_ES
dc.identifier.funderhttp://dx.doi.org/10.13039/501100000780es_ES
dc.identifier.funderhttp://dx.doi.org/10.13039/501100002809es_ES
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