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Protection of a single dose west nile virus recombinant subviral particle vaccine against lineage 1 or 2 strains and analysis of the cross-reactivity with usutu virus

AutorMerino-Ramos, Teresa; Blázquez, Ana Belén; Escribano-Romero, Estela; Cañas-Arranz, Rodrigo; Sobrino Castelló, Francisco ; Saiz, Juan Carlos; Martín-Acebes, Miguel Ángel
Fecha de publicación17-sep-2014
EditorPublic Library of Science
CitaciónPLoS ONE 9 (2014)
Resumen© 2014 Merino-Ramos et al. West Nile virus (WNV) is a neurovirulent mosquito-borne flavivirus. High WNV virulence was mainly associated with lineage 1 strains, but recent outbreaks have unveiled circulation of highly virulent lineage 2 strains. Co-expression of flavivirus prM and E glycoproteins drives the assembly of recombinant subviral particles (RSPs) that share antigenic features with virions. Mouse immunization with lineage 1 WNV RSPs induced a potent humoral response against WNV with production of neutralizing antibodies. A single inoculation of RSPs formulated with Al(OH)3as adjuvant protected mice against a lethal challenge with WNV strains from lineage 1 or 2. The cross-reactivity of the response elicited by these RSPs was analyzed against the related flavivirus Usutu virus (USUV), which shares multiple ecological and antigenic features with WNV. Immunization with WNV-RSPs increased specific, although low, antibody titers found upon subsequent USUV infection. Copyright:
URIhttp://hdl.handle.net/10261/125258
DOI10.1371/journal.pone.0108056
Identificadoresdoi: 10.1371/journal.pone.0108056
issn: 1932-6203
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