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Polμ deficiency increases resistance to oxidative damage and delays liver aging

AutorEscudero, Beatriz; Blanco, Luis ; Bernard, Antonio
Fecha de publicación1-abr-2014
EditorPublic Library of Science
CitaciónPLoS ONE 9 (2014)
ResumenPolμ is an error-prone PolX polymerase that contributes to classical NHEJ DNA repair. Mice lacking Polm (Polμ-/-) show altered hematopoiesis homeostasis and DSB repair and a more pronounced nucleolytic resection of some V(D)J junctions. We previously showed that Polμ-/- mice have increased learning capacity at old ages, suggesting delayed brain aging. Here we investigated the effect of Polμ-/- deficiency on liver aging. We found that old Polμ-/- mice (>20 month) have greater liver regenerative capacity compared with wt animals. Old Polμ-/- liver showed reduced genomic instability and increased apoptosis resistance. However, Polμ-/- mice did not show an extended life span and other organs (e.g., heart) aged normally. Our results suggest that Polμ deficiency activates transcriptional networks that reduce constitutive apoptosis, leading to enhanced liver repair at old age. © 2014 Escudero et al.
URIhttp://hdl.handle.net/10261/125246
DOI10.1371/journal.pone.0093074
Identificadoresdoi: 10.1371/journal.pone.0093074
issn: 1932-6203
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