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eEF1A mediates the nuclear export of SNAG-containing proteins via the exportin5-aatRNA complex

AuthorsMingot, José Manuel; Vega, Sonia; Cano, Amparo ; Portillo, Francisco ; Nieto, M. Ángela
Issue Date2013
CitationTEMTIA 2013
AbstractExportin5 mediates the nuclear export of dsRNAs including pre-miRNAs, adenoviral RNAs and tRNAs. When tRNAs are aminoacylated, the aatRNA-Exportin5 complex recruits and co-exports the translation elongation factor eEF1A. Here we show that eEF1A recruits Snail transcription factors, facilitating their export to the cytoplasm in association with the aatRNA-Exportin5 complex. Snail binds to eEF1A through the SNAG domain, a novel protein nuclear export signal (NES) present in several transcription factor families, and this binding is regulated by phosphorylation. Thus, we describe a nuclear role for eEF1A and provide a novel mechanism for protein nuclear export that attenuates the activity of SNAG-containing transcription factors.
DescriptionResumen del trabajo presentado al "6th International EMT Meeting:Symposium IV. Non-transcriptional regulation of EMT II" celebrado en Alicante (España) del 13 al 16 de noviembre de 2013.
Appears in Collections:(IIBM) Comunicaciones congresos
(IN) Comunicaciones congresos
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