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dc.contributor.authorMingot, José Manueles_ES
dc.contributor.authorVega, Soniaes_ES
dc.contributor.authorCano, Amparoes_ES
dc.contributor.authorPortillo, Franciscoes_ES
dc.contributor.authorNieto, M. Ángelaes_ES
dc.identifier.citationTEMTIA 2013es_ES
dc.descriptionResumen del trabajo presentado al "6th International EMT Meeting:Symposium IV. Non-transcriptional regulation of EMT II" celebrado en Alicante (España) del 13 al 16 de noviembre de 2013.es_ES
dc.description.abstractExportin5 mediates the nuclear export of dsRNAs including pre-miRNAs, adenoviral RNAs and tRNAs. When tRNAs are aminoacylated, the aatRNA-Exportin5 complex recruits and co-exports the translation elongation factor eEF1A. Here we show that eEF1A recruits Snail transcription factors, facilitating their export to the cytoplasm in association with the aatRNA-Exportin5 complex. Snail binds to eEF1A through the SNAG domain, a novel protein nuclear export signal (NES) present in several transcription factor families, and this binding is regulated by phosphorylation. Thus, we describe a nuclear role for eEF1A and provide a novel mechanism for protein nuclear export that attenuates the activity of SNAG-containing transcription factors.es_ES
dc.titleeEF1A mediates the nuclear export of SNAG-containing proteins via the exportin5-aatRNA complexes_ES
dc.typecomunicación de congresoes_ES
dc.description.peerreviewedPeer reviewedes_ES
Appears in Collections:(IIBM) Comunicaciones congresos
(IN) Comunicaciones congresos
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