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Title

Synthesis and in vitro inhibition properties of siRNA conjugates carrying acridine and quindoline moieties

AuthorsAviñó, Anna ; Eritja Casadellà, Ramón ; Ocampo, Sandra M. ; Perales, José C.
KeywordsInhibitors
Oligoribonucleotides
RNA
siRNA
Quindoline
Acridine
Threoninol
Tumor necrosis factor
Issue DateMar-2012
PublisherJohn Wiley & Sons
CitationChemistry and Biodiversity
AbstractThe synthesis of RNA molecules carrying acridine or quindoline residues at their 3′- and 5′-termini is reported. These conjugates are fully characterized by MALDI-TOF mass spectrometry. Modified siRNA duplexes carrying acridine or quindoline moieties were evaluated for inhibition of the tumor necrosis factor. The conjugates showed inhibitory properties similar to those of unmodified RNA duplexes in HeLa cells transfected with oligofectamine. The fluorescent properties of acridine derivatives allow direct observation of the cytoplasmatic distribution of modified siRNA inside the cells
Publisher version (URL)DOI: 10.1002/cbdv.201100321
URIhttp://hdl.handle.net/10261/125225
DOIhttp://dx.doi.org/10.1002/cbdv.201100321
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