English   español  
Por favor, use este identificador para citar o enlazar a este item: http://hdl.handle.net/10261/125219
COMPARTIR / IMPACTO:
Estadísticas
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:
Título

Thrombin Binding Aptamer, more than a Simple Aptamer: Chemically Modified Derivatives and Biomedical Applications

AutorAviñó, Anna; Eritja Casadellà, Ramón; Fàbrega, Carme; Tintoré, María
Palabras claveAnticoagulant
Aptamer
DNA
G-quadruplex
TBA
Oligonucleotide synthesis
Thrombin binding aptamer
Thrombin
Fecha de publicaciónmay-2012
EditorBentham Science Publishers
CitaciónCurrent Pharmaceutical Design
ResumenThe thrombin binding aptamer (TBA) is a well characterized chair-like, antiparallel quadruplex structure that binds specifically to thrombin at nanomolar concentrations and therefore it has interesting anticoagulant properties. In this article we review the research involved in the development of new TBA derivatives with improved anticoagulant properties as well as the use of the TBA as a model compound for the study of quadruplex structures. Specifically, we describe the impact of modified nucleosides and non-natural backbones in the guanine tetrads or in the loops and the introduction of pendant groups at the 3' or 5'-ends. The modified oligonucleotides are shown to be excellent tools for the understanding of the molecular structure of the TBA and its folding properties. Finally, we review the use of the TBA-Thrombin recognition system for the development of analytical tools based on the TBA folding.
Versión del editorDOI: 10.2174/138161212799958387
URIhttp://hdl.handle.net/10261/125219
DOI10.2174/138161212799958387
Aparece en las colecciones: (IQAC) Artículos
Ficheros en este ítem:
Fichero Descripción Tamaño Formato  
TBA_2012CurrPharmDes.pdfArtículo principal314,58 kBAdobe PDFVista previa
Visualizar/Abrir
Mostrar el registro completo
 

Artículos relacionados:


NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.