English   español  
Por favor, use este identificador para citar o enlazar a este item: http://hdl.handle.net/10261/12516
Título

The structure of the C-terminal domain of the protein kinase AtSOS2 bound to the calcium sensor AtSOS3

AutorSánchez-Barrena, María José ; Fujii, Hiroaki; Angulo, Iván ; Martínez-Ripoll, Martín ; Zhu, Jian-Kang; Albert, Armando
Palabras claveAtSOS3
Protein kinases
Fecha de publicación11-may-2007
EditorElsevier
CitaciónMolecular Cell (2007) 26, 427-435
ResumenThe plant SOS2 family of protein kinases and their interacting activators, the SOS3 family of calcium-binding proteins, function together in decoding calcium signals elicited by different environmental stimuli. SOS2 is activated by Ca-SOS3 and subsequently phosphorylates the ion transporter SOS1 to bring about cellular ion homeostasis under salt stress. In addition to possessing the kinase activity, members of the SOS2 family of protein kinases can bind to protein phosphatase 2Cs. The crystal structure of the binary complex of Ca-SOS3 with the C-terminal regulatory moiety of SOS2 resolves central questions regarding the dual function of SOS2 as a kinase and a phosphatase-binding protein. A comparison with the structure of unbound SOS3 reveals the basis of the molecular function of this family of kinases and their interacting calcium sensors. Furthermore, our study suggests that the structure of the phosphataseinteraction domain of SOS2 defines a scaffold module conserved from yeast to human.
DescripciónDisponible en: http://www.xtal.iqfr.csic.es/publications/molcell2007.pdf
Versión del editorhttp://dx.doi.org/10.1016/j.molcel.2007.04.013
URIhttp://hdl.handle.net/10261/12516
DOI10.1016/j.molcel.2007.04.013
ISSN1097-2765
Aparece en las colecciones: (IQFR) Artículos
Ficheros en este ítem:
No hay ficheros asociados a este ítem.
Mostrar el registro completo
 

Artículos relacionados:


NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.