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http://hdl.handle.net/10261/125104
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dc.contributor.author | Hernández-Sánchez, Marta | - |
dc.contributor.author | Poch, Enric | - |
dc.contributor.author | Guasch, Rosa M. | - |
dc.contributor.author | Ortega, Joaquín | - |
dc.contributor.author | López-Almela, Inmaculada | - |
dc.contributor.author | Palmero, Ignacio | - |
dc.contributor.author | Pérez-Roger, Ignacio | - |
dc.date.accessioned | 2015-11-16T12:10:44Z | - |
dc.date.available | 2015-11-16T12:10:44Z | - |
dc.date.issued | 2015 | - |
dc.identifier | doi: 10.18632/oncotarget.4127 | - |
dc.identifier | e-issn: 1949-2553 | - |
dc.identifier.citation | Oncotarget 6(19): 17479-17490 (2015) | - |
dc.identifier.uri | http://hdl.handle.net/10261/125104 | - |
dc.description | This is an open-access article distributed under the terms of the Creative Commons Attribution License. | - |
dc.description.abstract | RhoE is a small GTPase involved in the regulation of actin cytoskeleton dynamics, cell cycle and apoptosis. The role of RhoE in cancer is currently controversial, with reports of both oncogenic and tumor-suppressive functions for RhoE. Using RhoE-deficient mice, we show here that the absence of RhoE blunts contact-inhibition of growth by inhibiting p27Kip1 nuclear translocation and cooperates in oncogenic transformation of mouse primary fibroblasts. Heterozygous RhoE+/gt mice are more susceptible to chemically induced skin tumors and RhoE knock-down results in increased metastatic potential of cancer cells. These results indicate that RhoE plays a role in suppressing tumor initiation and progression. | - |
dc.description.sponsorship | This work was supported by grants from the Instituto de Salud Carlos III (to IPR and RMG), MINECO SAF2013-49176-C2-1-R and SAF2012-32117 (to IPR and IP, respectively) and Universidad CEU Cardenal Herrera Santander-Copernicus (to IPR). The work was also supported by fellowships from the Generalitat Valenciana (to MHS). | - |
dc.publisher | Impact Journals | - |
dc.relation | info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/SAF2013-49176-C2-1-R | - |
dc.relation.isversionof | Publisher's version | - |
dc.rights | openAccess | - |
dc.title | RhoE is required for contact inhibition and negatively regulates tumor initiation and progression | - |
dc.type | artículo | - |
dc.identifier.doi | 10.18632/oncotarget.4127 | - |
dc.relation.publisherversion | http://dx.doi.org/10.18632/oncotarget.4127 | - |
dc.date.updated | 2015-11-16T12:10:44Z | - |
dc.description.version | Peer Reviewed | - |
dc.language.rfc3066 | eng | - |
dc.rights.license | http://creativecommons.org/licenses/by/3.0/ | - |
dc.contributor.funder | Generalitat Valenciana | - |
dc.contributor.funder | Ministerio de Economía y Competitividad (España) | - |
dc.contributor.funder | Universidad CEU Cardenal Herrera | - |
dc.contributor.funder | Instituto de Salud Carlos III | - |
dc.contributor.funder | Fundación Banco Santander | - |
dc.relation.csic | Sí | - |
dc.identifier.funder | http://dx.doi.org/10.13039/501100003359 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100003329 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100004587 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/100008049 | es_ES |
dc.identifier.pmid | 26036260 | - |
dc.type.coar | http://purl.org/coar/resource_type/c_6501 | es_ES |
item.openairetype | artículo | - |
item.cerifentitytype | Publications | - |
item.grantfulltext | open | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.fulltext | With Fulltext | - |
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RhoErequired.pdf | 1,34 MB | Adobe PDF | Visualizar/Abrir |
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