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http://hdl.handle.net/10261/125090
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Campo DC | Valor | Lengua/Idioma |
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dc.contributor.author | Linares, Daniel M. | es_ES |
dc.contributor.author | Río Lagar, Beatriz del | es_ES |
dc.contributor.author | Redruello, Begoña | es_ES |
dc.contributor.author | Ladero Losada, Víctor Manuel | es_ES |
dc.contributor.author | Martín, M. Cruz | es_ES |
dc.contributor.author | Fernández García, María | es_ES |
dc.contributor.author | Ruas-Madiedo, Patricia | es_ES |
dc.contributor.author | Álvarez González, Miguel Ángel | es_ES |
dc.date.accessioned | 2015-11-16T11:02:43Z | - |
dc.date.available | 2015-11-16T11:02:43Z | - |
dc.date.issued | 2016-04-15 | - |
dc.identifier.citation | Food Chemistry Volume 197(Part A): 658–663 (2016) | es_ES |
dc.identifier.issn | 0308-8146 | - |
dc.identifier.uri | http://hdl.handle.net/10261/125090 | - |
dc.description.abstract | Tyramine and histamine, the most toxic biogenic amines (BA), are often found in high concentrations in certain foods. Prompted by the limited knowledge of BA toxicity, and increasing awareness of the risks associated with high intakes of dietary BA, the in vitro cytotoxicity of tyramine and histamine was investigated. Tyramine and histamine were toxic for HT29 intestinal cell cultures at concentrations commonly found in BA-rich food, as determined by real-time cell analysis. Surprisingly, tyramine had a stronger and more rapid cytotoxic effect than histamine. Their mode of action was also different, while tyramine caused cell necrosis, histamine induced apoptosis. To avoid health risks, the BA content of foods should be reduced and legal limits established for tyramine. | es_ES |
dc.description.sponsorship | This work was funded by the Spanish Ministry of Economy and Competitiveness (AGL2013-45431-R) and by the GRUPIN14-137 project, which is co-financed by the Plan for Science, Technology and Innovation of the Principality of Asturias 2014-2017 and the European Regional Development Funds. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Elsevier | es_ES |
dc.relation | info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/AGL2013-45431-R | es_ES |
dc.relation.isversionof | Postprint | es_ES |
dc.rights | openAccess | en_EN |
dc.subject | Biogenic amines | es_ES |
dc.subject | Cytotoxicity | es_ES |
dc.subject | Food security | es_ES |
dc.subject | Histamine | es_ES |
dc.subject | Tyramine | es_ES |
dc.title | Comparative analysis of the in vitro cytotoxicity of the dietary biogenic amines tyramine and histamine | es_ES |
dc.type | artículo | es_ES |
dc.identifier.doi | 10.1016/j.foodchem.2015.11.013 | - |
dc.description.peerreviewed | Peer reviewed | es_ES |
dc.relation.publisherversion | http://dx.doi.org/10.1016/j.foodchem.2015.11.013 | es_ES |
dc.embargo.terms | 2017-04-15 | es_ES |
dc.rights.license | http://creativecommons.org/licenses/by-nc-nd/4.0/ | - |
dc.contributor.funder | Ministerio de Economía y Competitividad (España) | es_ES |
dc.contributor.funder | Principado de Asturias | es_ES |
dc.contributor.funder | European Commission | es_ES |
dc.relation.csic | Sí | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100003329 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100000780 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/100011941 | es_ES |
dc.subject.uri | http://metadata.un.org/sdg/2 | es_ES |
dc.type.coar | http://purl.org/coar/resource_type/c_6501 | es_ES |
dc.subject.sdg | End hunger, achieve food security and improved nutrition and promote sustainable agriculture | es_ES |
item.openairetype | artículo | - |
item.grantfulltext | open | - |
item.cerifentitytype | Publications | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.fulltext | With Fulltext | - |
item.languageiso639-1 | en | - |
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vitro_cytotoxicity_Linares.pdf | 299,3 kB | Adobe PDF | Visualizar/Abrir |
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