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Title

New developments in the synthesis of oligonucleotide-peptide conjugates

AuthorsPortela, Cecilia; Mascareñas, José L. ; Alberico, Fernando; Eritja Casadellà, Ramón; Mazzini, Stefania; Caminal, Clara; Ramos, Roger; Ocampo, Sandra M.
KeywordsLeucine zipper
Oligonucleotide-peptide conjugates
Pyrimidines
t-butyl groups
Molecular Sequence Data
Oligonucleotides
DNA fragment
Issue DateAug-2007
PublisherTaylor & Francis
CitationNucleosides, Nucleotides and Nucleic Acids
AbstractThe stability of oligodeoxynucleotides to trifluoroacetic acid is studied. Pyrimidine oligonucleotides were stable in the conditions used for the removal of t-butyl groups. Oligonucleotide-3′-peptide conjugates carrying pyrimidine oligonucleotides are prepared stepwise using peptide-supports and Fmoc, t-butyl strategy. Using this strategy we have prepared an oligonucleotide-peptide conjugate containing as peptide the leucine-rich fragment of FOS, a transcription factor involved in many important cellular processes. This conjugate has a long peptide sequence with a large number of trifunctional amino acids.
Publisher version (URL)DOI: 10.1080/15257770701508216
URIhttp://hdl.handle.net/10261/124968
DOI10.1080/15257770701508216
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