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Title

Triplex formation using oligonucleotide clamps carrying 8-aminopurines

AuthorsAviñó, Anna ; Grimau, Marta G.; Alvira, Margarita; Eritja Casadellà, Ramón ; Gargallo, Raimundo; Orozco, Modesto; Bustamante González, Carlos Alberto
Keywords8-aminopurines
Binding properties
Oligonucleotide clamps
Triplex
Nucleic Acid Conformation
DNA
Oligonucleotides
Issue DateAug-2007
PublisherTaylor & Francis
CitationNucleosides, Nucleotides and Nucleic Acids
AbstractThe synthesis and properties of triplex-forming DNA clamps carrying 8-aminopurines are described. The stability of triple helices is enhanced by replacing purine bases with 8-aminopurine residues. These enhanced binding properties are used for the specific capture of polypyrimidine RNA/DNA sequences of interest.
Publisher version (URL)DOI: 10.1080/15257770701508398
URIhttp://hdl.handle.net/10261/124967
DOI10.1080/15257770701508398
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