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Title

A flexible method for the fabrication of gold nanostructures using oligonucleotide derivatives

AuthorsAviñó, Anna ; Eritja Casadellà, Ramón ; Fitzmaurice, Donald J.; García De la Torre, Beatriz; Ongaro, Andrea; Stanca, Sarmiza Elena; DiSalvo, Andrea; Maninng, Brendan; Iacopino, Daniela
KeywordsDNA nanobiotechnology
Gold nanoparticles
Self-assembly
Oligonucleotides
DNA
Issue DateOct-2007
PublisherTaylor & Francis
CitationNucleosides, Nucleotides and Nucleic Acids
AbstractSeveral linear and branched DNA structures from 80-200 nm with a biotine molecule in the middle have been prepared. These structures have been decorated by addition of positively charged gold nanoparticles carrying 4-(dimethylamino)pyridine ligands. Streptavidin binds to the central biotine molecule introducing a 20 nm gap in the structure in which a biotinylated nanoparticle can be introduced. The simplest structure (80 nm, linear) is formed by 4 oligonucleotides. By changing some of these components changes on length, shape, and recognition system easily can be introduced.
Publisher version (URL)DOI: 10.1080/15257770701548675
URIhttp://hdl.handle.net/10261/124965
DOIhttp://dx.doi.org/10.1080/15257770701548675
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