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Título

Methylation status of IGFBP-3 as a useful clinical tool for deciding on a concomitant radiotherapy

AutorPernía, Olga ; Cortés-Sempere, María; Macías, María-Teresa ; Ibáñez de Cáceres, Inmaculada
Palabras claveHypermethylation
IGFBP-3
IGFIR/AKT
NSCLC
Radiotherapy
Fecha de publicación6-dic-2014
EditorLandes Bioscience
CitaciónEpigenetics : official journal of the DNA Methylation Society 9(11): 1446-1453 (2014)
Resumen© 2014 Taylor & Francis Group, LLC. The methylation status of the IGFBP-3 gene is strongly associated with cisplatin sensitivity in patients with non-small cell lung cancer (NSCLC). In this study, we found in vitro evidence that linked the presence of an unmethylated promoter with poor response to radiation. Our data also indicate that radiation might sensitize chemotherapy-resistant cells by reactivating IGFBP-3-expression through promoter demethylation, inactivating the PI3K/AKT pathway. We also explored the IGFBP-3 methylation effect on overall survival (OS) in a population of 40 NSCLC patients who received adjuvant therapy after R0 surgery. Our results indicate that patients harboring an unmethylated promoter could benefit more from a chemotherapy schedule alone than from a multimodality therapy involving radiotherapy and platinum-based treatments, increasing their OS by 2.5 y (p =.03). Our findings discard this epi-marker as a prognostic factor in a patient population without adjuvant therapy, indicating that radiotherapy does not improve survival for patients harboring an unmethylated IGFBP-3 promoter.
DescripciónOlga Pernía et al.
Versión del editorhttp://dx.doi.org/10.4161/15592294.2014.971626
URIhttp://hdl.handle.net/10261/124957
DOI10.4161/15592294.2014.971626
Identificadoresdoi: 10.4161/15592294.2014.971626
issn: 1559-2308
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