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Long-term reduction of T-cell intracellular antigen reveals a transcriptome associated with extracellular matrix and cell adhesion components

AuthorsNúñez, Mario; Sánchez-Jiménez, Carmen ; Alcalde, José ; Izquierdo, José M.
Issue Date18-Aug-2014
PublisherPublic Library of Science
CitationPLoS ONE 9 (2014)
Abstract© 2014 Nuñez et al. Knockdown of T-cell intracellular antigens TIA1 and TIAR contributes to a cellular phenotype characterised by uncontrolled proliferation and tumorigenesis. Massive-scale poly(A+) RNA sequencing of TIA1 or TIAR-knocked down HeLa cells reveals transcriptome signatures comprising genes and functional categories potentially able to modulate several aspects of membrane dynamics associated with extracellular matrix and focal/cell adhesion events. The transcriptomic heterogeneity is the result of differentially expressed genes and RNA isoforms generated by alternative splicing and/or promoter usage. These results suggest a role for TIA proteins in the regulation and/or modulation of cellular homeostasis related to focal/cell adhesion, extracellular matrix and membrane and cytoskeleton dynamics. Copyright:
Identifiersdoi: 10.1371/journal.pone.0113141
issn: 1932-6203
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