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Título

Long-term reduction of T-cell intracellular antigen reveals a transcriptome associated with extracellular matrix and cell adhesion components

AutorNúñez, Mario; Sánchez-Jiménez, Carmen; Alcalde, José; Izquierdo, José M.
Fecha de publicación18-ago-2014
EditorPublic Library of Science
CitaciónPLoS ONE 9 (2014)
Resumen© 2014 Nuñez et al. Knockdown of T-cell intracellular antigens TIA1 and TIAR contributes to a cellular phenotype characterised by uncontrolled proliferation and tumorigenesis. Massive-scale poly(A+) RNA sequencing of TIA1 or TIAR-knocked down HeLa cells reveals transcriptome signatures comprising genes and functional categories potentially able to modulate several aspects of membrane dynamics associated with extracellular matrix and focal/cell adhesion events. The transcriptomic heterogeneity is the result of differentially expressed genes and RNA isoforms generated by alternative splicing and/or promoter usage. These results suggest a role for TIA proteins in the regulation and/or modulation of cellular homeostasis related to focal/cell adhesion, extracellular matrix and membrane and cytoskeleton dynamics. Copyright:
URIhttp://hdl.handle.net/10261/124919
DOI10.1371/journal.pone.0113141
Identificadoresdoi: 10.1371/journal.pone.0113141
issn: 1932-6203
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