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A straightforward synthesis of 5′-peptide oligonucleotide conjugates using Nα-Fmoc-protected amino acids

AuthorsOcampo, Sandra M.; Alberico, Fernando; Fernández, Irene F.; Vilaseca, Marta; Eritja Casadellà, Ramón
Keywordsfluorene derivative
amino acid
chemical structure
Issue DateSep-2005
PublisherAmerican Chemical Society
CitationOrganic Letters
Abstract(Chemical Equation Presented) 5′-Peptide oligonucleotide conjugates were prepared stepwise on a single support using Nα-Fmoc- protected amino acids and unprotected phosphate groups. The method uses commercially available reagents and is successful with most natural amino acids. The simplicity of the method may encourage researchers to prepare new oligonucleotide-peptide conjugates with novel properties.
Publisher version (URL)DOI: 10.1021/ol0514698
Appears in Collections:(IQAC) Artículos
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