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Title

Synthesis of oligoribonucleotides containing 4-thiouridine using the convertible nucleoside approach and the 1-(2-fluorophenyl)-4-methoxypiperidin-4- yl group

AuthorsAviñó, Anna ; Güimil García, Ramón; Eritja Casadellà, Ramón
Keywords1 (2 fluorophenyl) 4 methoxypiperidin 4 yl
2 nitrophenol
hydrogen sulfide
nucleoside derivative
RNA
triazole derivative
Oligoribonucleotides
Nucleosides
Thiouridine
Piperidines
Issue Date2004
PublisherTaylor & Francis
CitationNucleosides, Nucleotides and Nucleic Acids
AbstractOligoribonucleotides containing 4-thiouridine were prepared using the Fpmp group for protection of the 2′-OH. Two uridine derivatives with the 1,2,4-triazolyl and the 2-nitrophenyl groups at position 4 were used to obtain 4-thiouridine by postsynthetic substitution with sodium hydrogen sulfide. Both uridine derivatives allow the preparation of the desired oligonucleotides in good yields.
Publisher version (URL)DOI: 10.1081/NCN-200034044
URIhttp://hdl.handle.net/10261/124860
DOI10.1081/NCN-200034044
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