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Title

Synthesis of oligonucleotide-peptide conjugates carrying the c-myc peptide epitope as recognition system

AuthorsFrieden, Miriam; Eritja Casadellà, Ramón ; Aviñó, Anna ; Tarrasón, Gema; Escorihuela, Marta; Piulats, Jaume
Keywordsoligonucleotide
peptide nucleic acid
metabolism
Proto-Oncogene Proteins c-myc
Issue Date2004
PublisherJohn Wiley & Sons
CitationChemistry and Biodiversity
AbstractOligonucleotide-peptide conjugates 1-3 were prepared by sequential addition of the appropriate Boc-protected amino acids, followed by nucleoside phosphoramidites in the same support. These molecules are designed to be used for triplex formation and for the directed assembly of nanomaterials. The structures of the desired oligonucleotide-peptide conjugates were confirmed by mass spectrometry on small oligonucleotide-peptide conjugates, by gel electrophoresis, and by hybridization with complementary oligonucleotides. Oligonucleotides carrying the c-myc peptide were specifically recognized by the anti-c-myc monoclonal antibody.
Publisher version (URL)DOI: 10.1002/cbdv.200490075
URIhttp://hdl.handle.net/10261/124823
DOI10.1002/cbdv.200490075
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