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Título

Serotonin 5-HT<inf>4</inf> receptors and forebrain cholinergic system: receptor expression in identified cell populations

AutorPeñas-Cazorla, Raúl; Vilaró, Maria Teresa
Palabras claveAcetylcholine release
Basal forebrain GABAergic neurons
Basal forebrain glutamatergic neurons
Hippocampus
Nucleus basalis of Meynert
Septal nuclei
Fecha de publicación3-sep-2014
EditorSpringer
CitaciónBrain Structure and Function 220(6): 3413-3434 (2015)
Resumen© 2014, Springer-Verlag Berlin Heidelberg. Activation of serotonin 5-HT<inf>4</inf> receptors has pro-cognitive effects on memory performance. The proposed underlying neurochemical mechanism is the enhancement of acetylcholine release in frontal cortex and hippocampus elicited by 5-HT<inf>4</inf> agonists. Although 5-HT<inf>4</inf> receptors are present in brain areas related to cognition, e.g., hippocampus and cortex, the cellular localization of the receptors that might modulate acetylcholine release is unknown at present. We have analyzed, using dual label in situ hybridization, the cellular localization of 5-HT<inf>4</inf> receptor mRNA in identified neuronal populations of the rat basal forebrain, which is the source of the cholinergic innervation to cortex and hippocampus. 5-HT<inf>4</inf> receptor mRNA was visualized with isotopically labeled oligonucleotide probes, whereas cholinergic, glutamatergic, GABAergic and parvalbumin-synthesizing neurons were identified with digoxigenin-labeled oligonucleotide probes. 5-HT<inf>4</inf> receptor mRNA was not detected in the basal forebrain cholinergic cell population. In contrast, basal forebrain GABAergic, parvalbumin synthesizing, and glutamatergic cells contained 5-HT<inf>4</inf> receptor mRNA. Hippocampal and cortical glutamatergic neurons also express this receptor. These results indicate that 5-HT<inf>4</inf> receptors are not synthesized by cholinergic cells, and thus would be absent from cholinergic terminals. In contrast, several non-cholinergic cell populations within the basal forebrain and its target hippocampal and cortical areas express these receptors and are thus likely to mediate the enhancement of acetylcholine release elicited by 5-HT<inf>4</inf> agonists.
Versión del editorhttp://dx.doi.org/10.1007/s00429-014-0864-z
URIhttp://hdl.handle.net/10261/124736
DOI10.1007/s00429-014-0864-z
Identificadoresdoi: 10.1007/s00429-014-0864-z
issn: 1863-2661
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