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Production of feather hydrolysates with antioxidant, angiotensin-I converting enzyme- and dipeptidyl peptidase-IV-inhibitory activities

AutorFontoura, Roberta; Daroit, Daniel J.; Correa, Ana P.; Meira, Stela M.; Mosquera, Mauricio ; Brandelli, Adriano
Fecha de publicación2014
EditorElsevier
CitaciónNew Biotechnology 31: 506- 513 (2014)
Resumen© 2014 Elsevier B.V. The antioxidant and antihypertensive activities of feather hydrolysates obtained with the bacterium Chryseobacterium sp. kr6 were investigated. Keratin hydrolysates were produced with different concentrations of thermally denatured feathers (10-75gl-1) and initial pH values (6.0-9.0). Soluble proteins accumulated in high amounts in media with 50 and 75gl-1 of feathers, reaching values of 18.5 and 22mgml-1, respectively, after 48 hours of cultivation. In media with 50gl-1 of feathers, initial pH had minimal effect after 48 hours. Maximal protease production was observed after 24 hours of cultivation, and feather concentration and initial pH values showed no significant effect on enzyme yields at this time. Feather hydrolysates displayed in vitro antioxidant properties, and optimal antioxidant activities were observed in cultures with 50gl-1 feathers, at initial pH 8.0, after 48 hours growth at 30°C. Also, feather hydrolysates were demonstrated to inhibit the angiotesin I-converting enzyme by 65% and dipeptidyl peptidase-IV by 44%. The bioconversion of an abundant agroindustrial waste such as chicken feathers can be utilized as a strategy to obtain hydrolysates with antioxidant and antihypertensive activities. Feather hydrolysates might be employed as supplements in animal feed, and also as a potential source of bioactive molecules for feed, food and drug development.
URIhttp://hdl.handle.net/10261/124706
DOI10.1016/j.nbt.2014.07.002
Identificadoresdoi: 10.1016/j.nbt.2014.07.002
issn: 1876-4347
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